{"id":76230,"date":"2018-03-09T23:21:35","date_gmt":"2018-03-09T23:21:35","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alcoholismo-cronico-y-estres-oxidativo-mitocondrial-en-higado-posible-prevencion-mediante-la-administracion-de-antioxidantes\/"},"modified":"2018-03-09T23:21:35","modified_gmt":"2018-03-09T23:21:35","slug":"alcoholismo-cronico-y-estres-oxidativo-mitocondrial-en-higado-posible-prevencion-mediante-la-administracion-de-antioxidantes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/alcoholismo-cronico-y-estres-oxidativo-mitocondrial-en-higado-posible-prevencion-mediante-la-administracion-de-antioxidantes\/","title":{"rendered":"Alcoholismo cronico y estres oxidativo mitocondrial en higado. posible prevencion mediante la administracion de antioxidantes."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mi\u00f1ana Serrano Juan  Bautista <\/strong><\/h2>\n<p>El alcoholismo cr\u00f3nico repercute de manera directa y grave sobre la salud p\u00fablica, de hecho se estima que es responsable del 6% del total de las muertes anuales. La metabolizaci\u00f3n del etanol se realiza principalmente siguiendo un proceso de tipo oxidativo. Tradicionalmente se ha pensado que la actividad del sistema meos, que se encuentra inducida en el alcoholismo cr\u00f3nico, es la responsable de la producci\u00f3n de especies oxidantes asociada al metabolismo del etanol y por tanto la responsable de los da\u00f1os ocasionados por el consumo cr\u00f3nico de etanol. Nuestros resultados concenden un papel fundamental a la actividad aldeh\u00eddo deshidrogenasa (aldh) y al incremento en la concentraci\u00f3n intramitocondrial de nadh derivado de su actividad. adem\u00e1s, proponemos un modelo dual de muerte celular por apoptosis para los hepatocitos de ratas alcoh\u00f3licas en el que el ligando del sistema cd95\/fas jugar\u00eda un importante papel. Se ha observado que la administraci\u00f3n de s-adenosil-l-metionina (sam) previene tanto el estr\u00e9s oxidativo como la muerte celular en nuestro modelo experimental. En estudios realizados en humanos se revela un aumento en los \u00edndice de estr\u00e9s oxidativo relacionado con la ingesta diaria de etanol m\u00e1s que con el propio estado hep\u00e1tico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alcoholismo cronico y estres oxidativo mitocondrial en higado. posible prevencion mediante la administracion de antioxidantes.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alcoholismo cronico y estres oxidativo mitocondrial en higado. posible prevencion mediante la administracion de antioxidantes. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mi\u00f1ana Serrano Juan  Bautista <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/09\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Sastre Belloch Juan  Jose<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Vi\u00f1a ribes <\/li>\n<li>consuelo Guerri sirera (vocal)<\/li>\n<li>Jos\u00e9 Juan Garcia marin (vocal)<\/li>\n<li> Rodrigo gomez  Jos\u00e9 Manuel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mi\u00f1ana Serrano Juan Bautista El alcoholismo cr\u00f3nico repercute de manera directa y grave sobre la salud p\u00fablica, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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