{"id":76252,"date":"2018-03-09T23:21:35","date_gmt":"2018-03-09T23:21:35","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/epigenetic-transcriptional-repression-of-tumor-suppesor-genes-and-its-reversion-by-drugs\/"},"modified":"2018-03-09T23:21:35","modified_gmt":"2018-03-09T23:21:35","slug":"epigenetic-transcriptional-repression-of-tumor-suppesor-genes-and-its-reversion-by-drugs","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/epigenetic-transcriptional-repression-of-tumor-suppesor-genes-and-its-reversion-by-drugs\/","title":{"rendered":"Epigenetic transcriptional repression of tumor suppesor genes and its reversion by drugs."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Villar Garea <\/strong><\/h2>\n<p>Las alteraciones gen\u00e9licas y la desregulacl\u00f3n de tos mecanismos epigen\u00e9ticos colaboran en la iniciaci\u00f3n y progresi\u00f3n del c\u00e1ncer. Los defectos epigen\u00e9ticos son potencialmente reversibles, lo que ha suscitado la b\u00fasqueda de f\u00e1rmacos que selectivamente causen cambios en los patrones epigtm\u00e9licos de las c\u00e9lulas tumareles, oon la consiguiente diferenciaci\u00f3n, muerte y\/o parada de crecimiento de las mismas. Se han estudiado especialmente inhibidores de metillransferasas dedna (dnmt) e inhibidores de desacetilasas de histonas (hdac) dependientes de zn(ii). Los inhibidores de dnmts posibilitan la reactivaci\u00f3n de ganessilonciados mediante hipermetilaci\u00f3n de la isla cpg de su promotor y los inhibidores de hdac. De ganes silancfados vla hipoacetilaci\u00f3n de las histonas \u00e9lsociadas a su promotor. Apesar de sus prometedores efectos en cultivos celulares, muchas de estas sustancias presentan inconvenientes que limitan su aplicaci\u00f3n en quimioterapia. Por ello. En esta tesis:  1. Se han determinadolos afectos de procaina en la melitacion de dna yen la proliferaci\u00f3n de la linea celular mcf7. Procaina reduce la cantidad de  5-meltilcitosina en dna gen\u00f3mico, reactiva genes silenciados por hipermetilaci\u00f3n (rarb2) e induce parada del ciclo celular en mitosis.  2. Se han comparado siete inhibidores de hdacs dependientes da zn(ii) \u00e1cido butanoico \u00e1cido valproico. Ms.275. Tricostatina a(tsa),saha, pxd101 y nvp-laq824. existe una relaci\u00f3n astructura-actividad para los efectos de eslas sustancias en ensayos in vitro y en el crecimiento de mcf7.Adem\u00e1s, eunque estos inhibidores inducen cambios similares en acetilaci\u00f3n global de histonas, no todos reaclivan los mismos genes. Los niveles expresi\u00f3n de cdkn1a y gadd45b parecen determinar los efectos de estas sustanciasen el ciclo celular. En los promotores de los seis genes estudiados. La inhibici\u00f3n de hdacs aumenta la acetilaci\u00f3n de h4 y la dimetilaci\u00f3n de la tisina 4 de h3, mientras disminu<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Epigenetic transcriptional repression of tumor suppesor genes and its reversion by drugs.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Epigenetic transcriptional repression of tumor suppesor genes and its reversion by drugs. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Villar Garea <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/09\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manel Esteller Badosa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Cossio mora Fernando p. <\/li>\n<li>Antonio  vicente Ferrer montiel (vocal)<\/li>\n<li>esteban Ballester tar\u00edn (vocal)<\/li>\n<li>enrique Perez paya (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Villar Garea Las alteraciones gen\u00e9licas y la desregulacl\u00f3n de tos mecanismos epigen\u00e9ticos colaboran en la iniciaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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