{"id":76262,"date":"2018-03-09T23:21:39","date_gmt":"2018-03-09T23:21:39","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-de-proteccion-del-precondicionamiento-isquemico-en-el-trasplante-hepatico-de-injertos-esteatosicos\/"},"modified":"2018-03-09T23:21:39","modified_gmt":"2018-03-09T23:21:39","slug":"mecanismos-de-proteccion-del-precondicionamiento-isquemico-en-el-trasplante-hepatico-de-injertos-esteatosicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/fisiologia-humana\/mecanismos-de-proteccion-del-precondicionamiento-isquemico-en-el-trasplante-hepatico-de-injertos-esteatosicos\/","title":{"rendered":"Mecanismos de protecci\u00f3n del precondicionamiento isqu\u00e9mico en el trasplante hep\u00e1tico de injertos esteat\u00f3sicos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Esther Carrasco Chaumel <\/strong><\/h2>\n<p>Actualmente la principal limitaci\u00f3n del trasplante hep\u00e1tico es la falta de donantes. Para suplir la carencia de \u00f3rganos en muchas ocasiones se recurre al trasplante de \u00f3rganos que no son \u00f3ptimos para este fin, los denominados h\u00edgados sub\u00f3ptimos. Entre estos injertos destacan, por su preValencia, los h\u00edgados esteat\u00f3sicos. Los h\u00edgados esteat\u00f3sicos son m\u00e1s susceptibles a la lesi\u00f3n de isquemia\/reperfusi\u00f3n (i\/r) asociada al trasplante hep\u00e1tico que los h\u00edgados no grasos, y por ello presentan un mayor riesgo de disfunci\u00f3n tras ser trasplantados. Estudios llevados a cabo en modelos de isquemia normot\u00e9rmica se\u00f1alan hacia una mayor alteraci\u00f3n en la microcirculaci\u00f3n hep\u00e1tica, un aumento en la acumulaci\u00f3n de neutr\u00f3filos, una mayor liberaci\u00f3n de mediadores inflamatorios o una mayor lesi\u00f3n por estr\u00e9s oxidativo como posibles causas de esta mayor vulnerabilidad a la lesi\u00f3n de i\/r.     el precondicionamiento (pc) isqu\u00e9mico, una estrategia quir\u00fargica basada en la aplicaci\u00f3n de breves periodos de isquemia-reperfusi\u00f3n antes de someter al \u00f3rgano a una i\/r prolongada, ha resultado eficaz en la protecci\u00f3n de los h\u00edgados grasos frente a la lesi\u00f3n de i\/r en modelos de isquemia normot\u00e9rmica, donde se sugiere que la preservaci\u00f3n de los niveles de atp ejercida por el pc isqu\u00e9mica tendr\u00eda un papel determinante en la protecci\u00f3n del pc isqu\u00e9mico en este tipo de h\u00edgados.     diversos autores sugieren que el no y la ampk est\u00e1n implicados en la protecci\u00f3n del pc isqu\u00e9mico frente a la lesi\u00f3n de i\/r en modelos experimentales de isquemia normot\u00e9rmica.     sobre estas bases, en esta tesis se plantearon los siguientes objetivos:     1,- estudiar si el pc isqu\u00e9mico, modulando los mecanismos implicados en la mayor vulnerabilidad de los h\u00edgados grasos a la lesi\u00f3n de i\/r, protege frente a la lesi\u00f3n hep\u00e1tica y pulmonar asociada al trasplante de h\u00edgados grasos. As\u00ed como la evaluaci\u00f3n de la implicaci\u00f3n del no en los efectos protectores del pc isqu<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos de protecci\u00f3n del precondicionamiento isqu\u00e9mico en el trasplante hep\u00e1tico de injertos esteat\u00f3sicos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos de protecci\u00f3n del precondicionamiento isqu\u00e9mico en el trasplante hep\u00e1tico de injertos esteat\u00f3sicos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Esther Carrasco Chaumel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/09\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joan Rosell\u00f3 Cataflan<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Puig parellada <\/li>\n<li> Perales losa Jos\u00e9 Carlos (vocal)<\/li>\n<li>anna Seraf\u00edn canals (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Esther Carrasco Chaumel Actualmente la principal limitaci\u00f3n del trasplante hep\u00e1tico es la falta de donantes. Para suplir [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,817],"tags":[164594,164591,164592,26889,164593],"class_list":["post-76262","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-fisiologia-humana","tag-anna-serafin-canals","tag-esther-carrasco-chaumel","tag-joan-rosello-cataflan","tag-pedro-puig-parellada","tag-perales-losa-jose-carlos"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/76262","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=76262"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/76262\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=76262"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=76262"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=76262"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}