{"id":76270,"date":"2018-03-09T23:21:39","date_gmt":"2018-03-09T23:21:39","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/isquemia-cerebral-focal-transitoria-en-rata-caracterizacion-y-utilidad-del-modelo-de-sutura-intraluminal-en-el-estudio-de-estrategias-neuroprotectoras\/"},"modified":"2018-03-09T23:21:39","modified_gmt":"2018-03-09T23:21:39","slug":"isquemia-cerebral-focal-transitoria-en-rata-caracterizacion-y-utilidad-del-modelo-de-sutura-intraluminal-en-el-estudio-de-estrategias-neuroprotectoras","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/isquemia-cerebral-focal-transitoria-en-rata-caracterizacion-y-utilidad-del-modelo-de-sutura-intraluminal-en-el-estudio-de-estrategias-neuroprotectoras\/","title":{"rendered":"Isquemia cerebral focal transitoria en rata: caracterizaci\u00f3n y utilidad del modelo de sutura intraluminal en el estudio de estrategias neuroprotectoras."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Fernando Jes\u00fas P\u00e9rez Asensio <\/strong><\/h2>\n<p>Los accidentes cerebrovasculares agudos (\u00abictus\u00bb cerebrales) son trastornos neurol\u00f3gicos originados por la disminuci\u00f3n brusca del aporte sangu\u00edneo cerebral (\u00abisquemia cerebral\u00bb). La incidencia del ictus en espa\u00f1a es de unos 200 casos por cada 100.000 habitantes, lo que le sit\u00faa como la segunda causa de muerte, adem\u00e1s de la primera causa de invalidez permanente y la segunda de demencia.  a excepci\u00f3n de la aplicaci\u00f3n de la terapia trombol\u00edtica, actualmente no existe otro tratamiento eficaz del ictus en cl\u00ednica. El fundamento de las terapias neuroprotectoras propuestas en este estudio es impedir o limitar farmacol\u00f3gicamente la sucesi\u00f3n de reacciones celulares delet\u00e9reas desencadenadas por la isquemia y la reperfusi\u00f3n que acaban conduciendo a las c\u00e9lulas a la muerte, especialmente a aquellas situadas en la penumbra y que son susceptibles de ser rescatadas. El objetivo gen\u00e9rico del presente trabajo es, por tanto, evaluar el potencial neuroprotector de determinadas sustancias capaces de interferir sobre tres mecanismos fisiopatol\u00f3gicos implicados en el da\u00f1o cerebral producido por la isquemia-reperfusi\u00f3n: no, estr\u00e9s oxidativo e inflamaci\u00f3n. Dada la importancia que tiene el modelo experimental en los estudios sobre neuroprotecci\u00f3n, previamente se caracteriz\u00f3 el modelo de isquemia cerebral focal transitoria en rata, inducida por oclusi\u00f3n de la arteria cerebral media mediante la \u00abt\u00e9cnica de la sutura intraluminal\u00bb. durante los experimentos se monitoriz\u00f3 la perfusi\u00f3n cerebro-cortical (pcc) por l\u00e1ser-doppler en un \u00e1rea de penumbra isqu\u00e9mica, la presi\u00f3n arterial sist\u00e9mica (pas), la po2 y pco2, as\u00ed como el ph y la glucemia en sangre arterial. Finalmente se determin\u00f3 la afectaci\u00f3n neurol\u00f3gica y el tama\u00f1o de infarto cerebral resultante.  objetivos:  1- el primer objetivo concreto fue evaluar la hip\u00f3tesis de que el no producido por el enzima \u00f3xido n\u00edtrico sintasa inducible (inos) tras la isquemia origina el desc<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Isquemia cerebral focal transitoria en rata: caracterizaci\u00f3n y utilidad del modelo de sutura intraluminal en el estudio de estrategias neuroprotectoras.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Isquemia cerebral focal transitoria en rata: caracterizaci\u00f3n y utilidad del modelo de sutura intraluminal en el estudio de estrategias neuroprotectoras. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Fernando Jes\u00fas P\u00e9rez Asensio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/09\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Enrique Alborch Dom\u00ednguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Vila salinas Jos\u00e9 m. <\/li>\n<li> Moro sanchez M\u00aa angeles (vocal)<\/li>\n<li>ignacio Lizasoain hernandez (vocal)<\/li>\n<li>Ana Mar\u00eda Planas obradors (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernando Jes\u00fas P\u00e9rez Asensio Los accidentes cerebrovasculares agudos (\u00abictus\u00bb cerebrales) son trastornos neurol\u00f3gicos originados por la disminuci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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