{"id":76273,"date":"2018-03-09T23:21:39","date_gmt":"2018-03-09T23:21:39","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-antiangiogenico-y-antitumoral-de-la-1a-25-dihidroxivitamina-d3-y-el-factor-derivado-del-epitelio-pigmentario\/"},"modified":"2018-03-09T23:21:39","modified_gmt":"2018-03-09T23:21:39","slug":"efecto-antiangiogenico-y-antitumoral-de-la-1a-25-dihidroxivitamina-d3-y-el-factor-derivado-del-epitelio-pigmentario","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/efecto-antiangiogenico-y-antitumoral-de-la-1a-25-dihidroxivitamina-d3-y-el-factor-derivado-del-epitelio-pigmentario\/","title":{"rendered":"Efecto antiangiogenico y antitumoral de la 1a, 25 dihidroxivitamina d3 y el factor derivado del epitelio pigmentario"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Fernandez Garcia Nuria Isabel <\/strong><\/h2>\n<p>El desarrolle de un tumor depende no solo del crecimiento de las c\u00e9lulas tumorales sino tambi\u00e9n de su interacci\u00f3n con el microentornoen el que se desarrolla. Una parte importante de ese microentorno lo constituye la vascularizaci\u00f3n tumoral, o angiog\u00e9nesis, que es esencial tanto para el crecimiento del tumor primario como para la diseminaci\u00f3n de las c\u00e9lulas tumorales para formar focos metast\u00e1sicos distantes.  en este trabajo hemos estudiado aspectos relacionados con el mecanismo de acci\u00f3n antitumoral y antiangiog\u00e9nico de la 1a,25-dihidroxivitamina d3, un metabolito de la vitamina d, y del factor derivado del epitelio pigmentario (pedf). Se trata de dos mol\u00e9culas multifuncionales con capacidad para actuar sobre diversos tipos celulares. Hemos analizado su efecto antitumoral considerando la posibilidad de que act\u00faen de forma dual sobre la c\u00e9lula tumoral de forma directa, y sobre el microentorno tumoral, concretamente sobre la vasculatura tumoral.  hemos analizado el papel que juegan los factores id, miembros de una familia de prote\u00ednas reguladoras que inciden sobre el control de m\u00faltiples procesos celulares, en el mecanismo de acci\u00f3n antiproliferativo y prodiferenciador de la 1a,25-dihidroxivitamina d3 sobre la l\u00ednea celular sw480-adh derivada de un carcinoma de colon primario humano. Hemos demostrado que la represi\u00f3n transcripcional de id2 es un paso necesario en el efecto antiproliferativo de la 1a,25-dihidroxivitamina d3. La 1a,25-dihidroxivitamina d3 induce la expresi\u00f3n de id1, pero esta inducci\u00f3n no parece suficiente para regular el proceso de diferenciaci\u00f3n epitelial. Por \u00faltimo, la 1a,25-dihidroxivitamina d3 modula el efecto antiangiog\u00e9nico de las c\u00e9lulas sw480-adh, a trav\u00e9s de la expresi\u00f3n del factor inductor vegf y del inhibidor tsp-1.  hemos analizado al efecto del pedf sobre la l\u00ednea celular derivada de un melanoma humano primario ucd-mel-n. El pedf inhibe el crecimiento de tumores subcut\u00e1neos de me<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto antiangiogenico y antitumoral de la 1a, 25 dihidroxivitamina d3 y el factor derivado del epitelio pigmentario<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto antiangiogenico y antitumoral de la 1a, 25 dihidroxivitamina d3 y el factor derivado del epitelio pigmentario <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Fernandez Garcia Nuria Isabel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/09\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Benilde Jim\u00e9nez Cuenca<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Ort\u00edz de land\u00e1zuri busca <\/li>\n<li>Juan  Carlos Rodriguez-manzaneque escribano (vocal)<\/li>\n<li>Ana Rodriguez quesada (vocal)<\/li>\n<li>Luis Del peso ovalle (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernandez Garcia Nuria Isabel El desarrolle de un tumor depende no solo del crecimiento de las c\u00e9lulas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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