{"id":76283,"date":"2018-03-09T23:21:39","date_gmt":"2018-03-09T23:21:39","guid":{"rendered":""},"modified":"2018-03-09T23:21:39","modified_gmt":"2018-03-09T23:21:39","slug":"morfina-induce-la-formacion-de-complejos-multiproteicos-constituidos-por-protea%c2%adnas-g-protea%c2%adnas-rgs-y-elementos-de-la-va%c2%ada-del-rap-implicaciones-en-la-desensibilziacion-del-receptor","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/morfina-induce-la-formacion-de-complejos-multiproteicos-constituidos-por-protea%c2%adnas-g-protea%c2%adnas-rgs-y-elementos-de-la-va%c2%ada-del-rap-implicaciones-en-la-desensibilziacion-del-receptor\/","title":{"rendered":"Morfina induce la formaci\u00f3n de complejos multiproteicos constituidos por prote\u00ednas g, prote\u00ednas rgs y elementos de la v\u00edadel rap. implicaciones en  la desensibilziaci\u00f3n del receptor opioide u."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Rodr\u00edguez Mu\u00f1oz <\/strong><\/h2>\n<p>La desensibilizaci\u00f3n de gpcrs que conduce a la reducci\u00f3n de la se\u00f1al iniciada por los agonistas ha sido el proceso de regulaci\u00f3n m\u00e1s estudiado. Este fen\u00f3meno se ha caracterizado principalmente a nivel de la mol\u00e9cula del receptor, describiendose mecanismos que opera a nivel transcripcional, y\/o translacional, o que implican modificaciones covalentes de los receptores (fosforilaci\u00f3n y glicosilaciones) as\u00ed como regulaci\u00f3n de su asociaci\u00f3n con otras prote\u00ednas. Sin embargo, son cada vez m\u00e1s frecuentes los estudios que indican la p\u00e9rdida de se\u00f1alizaci\u00f3n de receptores g puede tambi\u00e9n producirse sin el concurso de fosforilaci\u00f3n, internalizaci\u00f3n y reactivaci\u00f3n.  en este sentido, la presente tesis doctoral hace un an\u00e1lisis sobre la importancia del sistema de transducci\u00f3n en la calidad de la analgesia inducida por los opioides en el sistema nervioso central del rat\u00f3n. En el estudio se ha observado que la tolerancia aguda inducida por morfina no se acompa\u00f1a por reducci\u00f3n de receptores u ni tampoco afecta su asociaci\u00f3n con los *, lo que surgiere la participaci\u00f3n de mecanismos post-receptor en este proceso de desensibilizaci\u00f3n.  en este sentido en sustancia gris priacueductal se ha observado la asociaci\u00f3n de receptores opioides u con prote\u00ednas reguladoras gi\/o\/z, ciertas rgs de la subfamilias r4, r7, r12 y rz, y tambi\u00e9n a prote\u00ednas tipo fosducina (phlpl), interacciones moduladas por el tratamiento agudo con morfina lo que les confiere relevancia funcional. La morfina reduce la asociaci\u00f3n prote\u00ednas gi\/o\/z con el receptor opioide u, recuper\u00e1ndose pocas horas despu\u00e9s de cesar los efectos de dosis d morfina que no producen tolerancia aguda. sin embargo, que interrumpida durante d\u00edas si la dosis de morfina induce desenssibilizaci\u00f3n del receptor.  la rgs9-2 juega un papel clave en la g\u00e9nesis de este fen\u00f3meno al retener a largo plazo subunidades galfai\/z activadas por el receptor. Los efectos opioides de cierta magnit<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Morfina induce la formaci\u00f3n de complejos multiproteicos constituidos por prote\u00ednas g, prote\u00ednas rgs y elementos de la v\u00edadel rap. implicaciones en  la desensibilziaci\u00f3n del receptor opioide u.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Morfina induce la formaci\u00f3n de complejos multiproteicos constituidos por prote\u00ednas g, prote\u00ednas rgs y elementos de la v\u00edadel rap. implicaciones en  la desensibilziaci\u00f3n del receptor opioide u. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Rodr\u00edguez Mu\u00f1oz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/09\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Javier Garz\u00f3n  Ni\u00f1o<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: \u00e1ngel Villar del fresno <\/li>\n<li> Puig riera de conias margarita m. (vocal)<\/li>\n<li>pilar S\u00e1nchez blazquez (vocal)<\/li>\n<li>carmen Guaza rodriguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Rodr\u00edguez Mu\u00f1oz La desensibilizaci\u00f3n de gpcrs que conduce a la reducci\u00f3n de la se\u00f1al iniciada por [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,189,483],"tags":[4663,6848,23656,164632,7569,19392],"class_list":["post-76283","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacodinamia","category-mecanismos-de-accion-de-los-farmacos","tag-angel-villar-del-fresno","tag-carmen-guaza-rodriguez","tag-javier-garzon-nino","tag-maria-rodriguez-munoz","tag-pilar-sanchez-blazquez","tag-puig-riera-de-conias-margarita-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/76283","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=76283"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/76283\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=76283"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=76283"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=76283"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}