{"id":76286,"date":"2018-03-09T23:21:39","date_gmt":"2018-03-09T23:21:39","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-vulnerabilidad-al-alcoholismo-perspectivas-terapeuticas-sobre-el-sistema-cannabinoide\/"},"modified":"2018-03-09T23:21:39","modified_gmt":"2018-03-09T23:21:39","slug":"estudio-de-la-vulnerabilidad-al-alcoholismo-perspectivas-terapeuticas-sobre-el-sistema-cannabinoide","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-vulnerabilidad-al-alcoholismo-perspectivas-terapeuticas-sobre-el-sistema-cannabinoide\/","title":{"rendered":"Estudio de la vulnerabilidad al alcoholismo: perspectivas terap\u00e9uticas sobre el sistema cannabinoide"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Antonio Lopez Moreno <\/strong><\/h2>\n<p>La tesis se basa en un conjunto de cinco experimentos cuyo hilo conductor es el estudio de la vulnerabilidad a la reca\u00edda al alcohol. Para ello se ha dise\u00f1ado una metodolog\u00eda original, basado en un modelo animal, imitando ciertos par\u00e1metros encontrados com\u00fanmente en consumidores de drogas de abuso, en este caso, la administraci\u00f3n de una droga (nicotina o un agonista cannabinoide) en abstinencia de la droga que consume el individuo rutinariamente (p.E.Farmacol\u00f3gicas para tratar la adicci\u00f3n al alcoholismo y el control de las reca\u00eddas. Estas estrategias est\u00e1n fundamentadas en la intervenci\u00f3n sobre el sistema cannabinoide.     en un primer experimento se ha demostrado que la reca\u00edda al alcohol se exacerba tras tratar el animal con nicotina durante el periodo de abstinencia. El animal consume m\u00e1s cantidad de alcohol durante m\u00e1s tiempo.     en un segundo experimento, se administr\u00f3 el agonista sint\u00e9tico cannabinoide win 55,212-2 durante la privaci\u00f3n de alcohol y se registr\u00f3 igualmente la potenciaci\u00f3n de la reca\u00edda al alcohol durante al menos dos semanas.     en el tercer experimento, se intent\u00f3 conocer el correlato neuroqu\u00edmo que pod\u00eda subyacer a los cambios conductuales que se hab\u00edan observado en los dos primeros experimentos. Por medio de la t\u00e9cnica de microdi\u00e1lisis se evalu\u00f3 la liberaci\u00f3n extracelular de dopamina en el \u00abshell\u00bb del n\u00facleo accumbens. Se observ\u00f3 que la exposici\u00f3n previa a la nicotina y al agonista cannabionoide win-55,212-2 produc\u00eda un bloqueo de la liberaci\u00f3n de dopamina inducida por alcohol. Sin embargo, en animales que no fueron pretratados con ninguna de las anteriores drogas, se pudo verificar la liberaci\u00f3n de dopamina producida por alcohol.     en el cuarto experimento, bas\u00e1ndose en el incremento de la reca\u00edda alcohol inducida por nicotina, se replic\u00f3 \u00e9ste, pero en el momento de la reca\u00edda se tratan los animales con el anatognista cannabinoides sr 141716, actualmente conocido como rimonabant. Los resulta<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la vulnerabilidad al alcoholismo: perspectivas terap\u00e9uticas sobre el sistema cannabinoide<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la vulnerabilidad al alcoholismo: perspectivas terap\u00e9uticas sobre el sistema cannabinoide <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Antonio Lopez Moreno <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/09\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Garcia Navarro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alfonso Moreno gonzalez <\/li>\n<li>Luis Stinus (vocal)<\/li>\n<li>walter Frata (vocal)<\/li>\n<li>Carlos Manuel Gonz\u00e1lez arag\u00f3n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Antonio Lopez Moreno La tesis se basa en un conjunto de cinco experimentos cuyo hilo conductor [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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