{"id":76306,"date":"2018-03-09T23:21:39","date_gmt":"2018-03-09T23:21:39","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesis-de-antitumorales-analogos-de-saframicina-y-ftalascidina\/"},"modified":"2018-03-09T23:21:39","modified_gmt":"2018-03-09T23:21:39","slug":"sa%c2%adntesis-de-antitumorales-analogos-de-saframicina-y-ftalascidina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sa%c2%adntesis-de-antitumorales-analogos-de-saframicina-y-ftalascidina\/","title":{"rendered":"S\u00edntesis de antitumorales an\u00e1logos de saframicina y ftalascidina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Francisco Gonz\u00e1lez Matilla <\/strong><\/h2>\n<p>En la presente tesis doctoral se ha llevado a cabo el estudio de una aproximaci\u00f3n a la s\u00edntesis del esqueleto pentac\u00edclico presente en los antibi\u00f3ticos antitumorales, m\u00e1s concretamente en saframicinas y ftalascidina.  nuestra estrategia se diferencia de otras porque en ellas en el anillo pirid\u00ednico de la porci\u00f3n isoquinol\u00ednica se forma en uno de los \u00faltimos pasos del proceso sint\u00e9tico, mientras que nosotros lo generamos en uno de los primeros pasos.  como compuestos de partida se propusieron las 3-arilmetilen-2, 5-piperazinodionas, que por posterior hidrogenaci\u00f3n se sometieron a diversos m\u00e9todos de n-alquilaci\u00f3n\/ciclaci\u00f3n, intentando que el proceso fuera vers\u00e1til de forma que permitiese cualquier tipo de sustituyentes en el anillo a y en la posici\u00f3n 6. La condensaci\u00f3n ald\u00f3lica\/hidrogenaci\u00f3n de los compuestos tric\u00edclicos y aldeh\u00eddos arom\u00e1ticos seguido de ciclaci\u00f3n reductora de los derivados as\u00ed obtenidos dio lugar a los sistemas pentac\u00edclicos y octac\u00edclicos.  se ha estudiado la actividad biol\u00f3gica de los compuestos obtenidos respecto a la et-743.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edntesis de antitumorales an\u00e1logos de saframicina y ftalascidina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edntesis de antitumorales an\u00e1logos de saframicina y ftalascidina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Francisco Gonz\u00e1lez Matilla <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/09\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Del Carmen Avenda\u00f1o L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: benito Alcaide ala\u00f1on <\/li>\n<li> Herranz herranz m. del rosario (vocal)<\/li>\n<li>julio Gonz\u00e1lez urones (vocal)<\/li>\n<li> Frencesch solloso Andr\u00e9s m. (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Francisco Gonz\u00e1lez Matilla En la presente tesis doctoral se ha llevado a cabo el estudio de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1412,17,416],"tags":[5891,164676,164675,164674,1906,17715],"class_list":["post-76306","post","type-post","status-publish","format-standard","hentry","category-compuestos-heterociclicos","category-quimica","category-quimica-organica","tag-benito-alcaide-alanon","tag-frencesch-solloso-andres-m","tag-herranz-herranz-m-del-rosario","tag-juan-francisco-gonzalez-matilla","tag-julio-gonzalez-urones","tag-maria-del-carmen-avendano-lopez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/76306","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=76306"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/76306\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=76306"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=76306"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=76306"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}