{"id":76308,"date":"2018-03-09T23:21:39","date_gmt":"2018-03-09T23:21:39","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/tumores-oligodendrogliales-valor-pronostico-de-algunas-variables-cla%c2%adnicas-histologicas-y-moleculares\/"},"modified":"2018-03-09T23:21:39","modified_gmt":"2018-03-09T23:21:39","slug":"tumores-oligodendrogliales-valor-pronostico-de-algunas-variables-cla%c2%adnicas-histologicas-y-moleculares","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/tumores-oligodendrogliales-valor-pronostico-de-algunas-variables-cla%c2%adnicas-histologicas-y-moleculares\/","title":{"rendered":"Tumores oligodendrogliales. valor pron\u00f3stico de algunas variables cl\u00ednicas. histol\u00f3gicas y moleculares"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Manuel Sep\u00falveda S\u00e1nchez <\/strong><\/h2>\n<p>Introducci\u00f3n y objetivos  los oligodendrogliomas han adquirido recientemente protagonismo en neuro-oncolog\u00eda debido a su respuesta a quimioterapia. Sin embargo, su diagn\u00f3stico y graduaci\u00f3n est\u00e1 sometido a una importante variabilidad interoboservador. En el presente trabajo se determinan los par\u00e1metros cl\u00ednicos, histol\u00f3gicos y moleculares que son predictores de la supervivencia y por tanto \u00fatiles en la gradaci\u00f3n de estos tumores.  adicionalmente se determina la relaci\u00f3n entre la expresi\u00f3n de cilina a, que est\u00e1 elevada en estos tumores, la prote\u00edna prb y la expresi\u00f3n de ki-67.  el mecanismo por el que los oligodendrogliomas son quimiosensibles no est\u00e1 a\u00fan determinado y se ha sugerido que existe un defecto en la reparaci\u00f3n del adn en estos tumores.  en el presente trabajo se determina el grado de expresi\u00f3n de la prote\u00edna reparadora del adn mgmt en estos tumores y su correlaci\u00f3n con la supervivencia en los casos tratados con radioterapia.  material y m\u00e9todos  se realiz\u00f3 un estudio retrospectivo de los 80 casos diagnosticados como tumor oligodendroglial en la secci\u00f3n de neuropatolog\u00eda del \u00abhospital universitario 12 de octubre\u00bb. Se revisaron sus caracter\u00edsticas histol\u00f3gicas cl\u00ednicas y radiol\u00f3gicas: para el estudio inmunohistoqu\u00edmico se construyeron tres matrices de tejido (\u00abtissue microarrays\u00bb). Para el estudio univariante de la supervivencia se utiliz\u00f3 el m\u00e9todo de log-rank y se desarroll\u00f3 un modelo de regresi\u00f3n de cox para el estudio multivariante.  resultados y conclusiones  la edad en el momento del diagn\u00f3stico, la captaci\u00f3n de contraste en la neuroimagen, la presencia de m\u00e1s de 3 mitosis por 10 campos de gran aumento y el porcentaje de astrocitos de la muestra fueron los factores independientes predictivos de la supervivencia.  es posible diferenciar los oligodendrogliomas de los oligoastrocitomas cuando el porcentaje de astrocitos es menor del 20%. Los casos anapl\u00e1sicos se diferencian por la<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Tumores oligodendrogliales. valor pron\u00f3stico de algunas variables cl\u00ednicas. histol\u00f3gicas y moleculares<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Tumores oligodendrogliales. valor pron\u00f3stico de algunas variables cl\u00ednicas. histol\u00f3gicas y moleculares <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Manuel Sep\u00falveda S\u00e1nchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/09\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Ramon Ricoy Campo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: juli\u00e1n Sanz esponeza <\/li>\n<li>esteban Ristol (vocal)<\/li>\n<li>Manuel Molina (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Manuel Sep\u00falveda S\u00e1nchez Introducci\u00f3n y objetivos los oligodendrogliomas han adquirido recientemente protagonismo en neuro-oncolog\u00eda debido a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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