{"id":76318,"date":"2018-03-09T23:21:43","date_gmt":"2018-03-09T23:21:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-administracion-del-gliotoxico-6-an-modifica-la-evolucion-de-las-lesiones-hipocampales-en-ratas-epilepticas\/"},"modified":"2018-03-09T23:21:43","modified_gmt":"2018-03-09T23:21:43","slug":"la-administracion-del-gliotoxico-6-an-modifica-la-evolucion-de-las-lesiones-hipocampales-en-ratas-epilepticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/neurologia\/la-administracion-del-gliotoxico-6-an-modifica-la-evolucion-de-las-lesiones-hipocampales-en-ratas-epilepticas\/","title":{"rendered":"La administraci\u00f3n del gliot\u00f3xico 6-an modifica la evoluci\u00f3n de las lesiones hipocampales en ratas epil\u00e9pticas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Susana Mezquita Regueiro <\/strong><\/h2>\n<p>El presente estudio pretende conocer la participaci\u00f3n de la estirpe glial en la patolog\u00eda epil\u00e9ptica, as\u00ed como las posibles pautas de su tratamiento. Para ello se utiliza un modelo animal epil\u00e9ptico que se consigue con la administraci\u00f3n de un neurot\u00f3xico, la pilocarpina, a ratas adultas.     posteriormente, y mediante la utilizaci\u00f3n de diversas t\u00e9cnicas de tinci\u00f3n  como son kl\u00ed\u00bcber-barrera, marcado de la prote\u00edna \u00e1cida fibrilar glial (gfap) y la combinaci\u00f3n de marcado gfap y un nissl, se estudia la evoluci\u00f3n neuronal y  glial a lo largo del tiempo en el cerebro del animal.     a pesar de observarse lesiones en varias zonas del cerebro de los animales epil\u00e9pticos, centramos el estudio en el \u00e1rea del hipocampo, por ser una zona ampliamente estudiada y donde se han observado lesiones similares en el humano. Las lesiones caracter\u00edsticas son la p\u00e9rdida de neuronas desde las primeras semanas de la lesi\u00f3n, fundamentalmente en el \u00e1rea ca1 del hipocampo y gliosis reactiva. La gliosis es m\u00e1s acusada transcurridas cuatro semanas despu\u00e9s de la administraci\u00f3n de la pilocarpina y los astrocitos reactivos permanecen en el \u00e1rea mucho tiempo despu\u00e9s hasta formar una cicatriz glial .     con la finalidad de alterar la formaci\u00f3n de las encionadas cicatrices gliales, posibles desencadenantes de las crisis epil\u00e9pticas, se administra un gliot\u00f3xico, 6-amino-nicotinamida, en distintos momentos. Considerando que seg\u00fan la bibliograf\u00eda consultada, los momentos de mayor formaci\u00f3n de astrocitos reactivos coinciden entre los 5 y 14 d\u00edas posesi\u00f3n administramos este gliot\u00f3xico, que tiene afinidad por los astrocitos que est\u00e1n en un proceso reactivo.     como resultado final, observamos que mejora notablemente el \u00e1rea en toros casos da\u00f1ada y que esa mejor\u00eda evoluciona favorablemente a lo largo del tiempo observ\u00e1ndose hipocampos similares al normal, carentes de cicatrices en animales catalogados en el estudio como cr\u00f3nicos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La administraci\u00f3n del gliot\u00f3xico 6-an modifica la evoluci\u00f3n de las lesiones hipocampales en ratas epil\u00e9pticas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La administraci\u00f3n del gliot\u00f3xico 6-an modifica la evoluci\u00f3n de las lesiones hipocampales en ratas epil\u00e9pticas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Susana Mezquita Regueiro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/09\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Leonor Hennequet Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ren\u00e9 Sarrat torreguitart <\/li>\n<li>Fernando Unda rodr\u00edguez (vocal)<\/li>\n<li>Juan  Jos\u00e9 Zarranz imirizaldu (vocal)<\/li>\n<li>Ana Torres del puerto (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Susana Mezquita Regueiro El presente estudio pretende conocer la participaci\u00f3n de la estirpe glial en la patolog\u00eda [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[8868,1880,12909],"tags":[4017,61975,13452,149177,8203,164700],"class_list":["post-76318","post","type-post","status-publish","format-standard","hentry","category-neuroanatomia-humana","category-neurologia","category-pais-vasco-euskal-herriko-unibertsitatea","tag-ana-torres-del-puerto","tag-fernando-unda-rodriguez","tag-juan-jose-zarranz-imirizaldu","tag-leonor-hennequet-fernandez","tag-rene-sarrat-torreguitart","tag-susana-mezquita-regueiro"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/76318","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=76318"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/76318\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=76318"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=76318"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=76318"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}