{"id":76351,"date":"2018-03-09T23:21:43","date_gmt":"2018-03-09T23:21:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-implicados-en-acciones-serotonergicas-vasculares-en-rinon-autoperfundido-de-ratas-normotensas-e-hipertensas-por-l-name\/"},"modified":"2018-03-09T23:21:43","modified_gmt":"2018-03-09T23:21:43","slug":"mecanismos-implicados-en-acciones-serotonergicas-vasculares-en-rinon-autoperfundido-de-ratas-normotensas-e-hipertensas-por-l-name","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacodinamia\/mecanismos-implicados-en-acciones-serotonergicas-vasculares-en-rinon-autoperfundido-de-ratas-normotensas-e-hipertensas-por-l-name\/","title":{"rendered":"Mecanismos implicados en acciones serotonergicas vasculares, en ri\u00f1on autoperfundido de ratas normotensas e hipertensas por l-name"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Jarque Fuertes M\u00aa Jes\u00fas <\/strong><\/h2>\n<p>En este trabajo de tesis doctoral se estudian las respuestas vasculares inducidas por 5-hidroxitriptamina (5-ht) en ri\u00f1\u00f3n autoperfundido de ratas normotensas e hipertensas por l-name, y se caracterizan los receptores y los posibles mecanismos de acci\u00f3n implicados en dichas respuestas. De igual modo, se estudia la relaci\u00f3n entre el sistema seroton\u00e9rgico y la neurotransmisi\u00f3n adren\u00e9rgica en este territorio. A trav\u00e9s de estudios funcionales (utilizando agonistas y antagonistas selectivos de los tipos y subtipos de receptores seroton\u00e9rgicos) se ha puesto de manifiesto que, en ratas normotensas, 5-ht induce vasoconstricci\u00f3n mediada principalmente por activaci\u00f3n de receptores 5-ht2c. La activaci\u00f3n de estos receptores produce un aumento en la formaci\u00f3n de angiotensina ii. El aumento del tono vascular renal con fenilefrina, permite evidenciar acciones seroton\u00e9rgicas vasodilatadoras locales, mediadas por activaci\u00f3n de receptores 5-ht1d y 5-ht1e\/f, que implican la liberaci\u00f3n de \u00f3xido n\u00edtrico (no) y la consiguiente activaci\u00f3n de la guanilato ciclasa.  el modelo de hipertensi\u00f3n por l-name, potencia las respuestas vasoconstrictoras de 5-ht e induce cambios en el subtipo de receptor implicado en esta respuesta, siendo en este caso el receptor 5-ht2a el principal responsable de la vasoconstricci\u00f3n renal. Mediante estudios moleculares de western blotting, se he puesto de manifiesto que en tejido renal de ratas normotensas e hipertensas por l-name se encuentran presentes los receptores 5-ht1a, 5-ht1b, 5-ht1d, 5-ht2a, 5-ht2b, 5-ht2c y 5-ht7 y que la hipertensi\u00f3n por l-name modifica significativamente la expresi\u00f3n del subtipo 5-ht2a.  por \u00faltimo, se ha puesto de manifiesto que a nivel renal en ratas normotensas, existen mecanismos seroton\u00e9rgicos inhibidores de la neurotransmisi\u00f3n simp\u00e1tica relacionados con receptores 5-ht1d, cuya activaci\u00f3n implica un aumento de la liberaci\u00f3n de no.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos implicados en acciones serotonergicas vasculares, en ri\u00f1on autoperfundido de ratas normotensas e hipertensas por l-name<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos implicados en acciones serotonergicas vasculares, en ri\u00f1on autoperfundido de ratas normotensas e hipertensas por l-name <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Jarque Fuertes M\u00aa Jes\u00fas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/09\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis San Rom\u00e1n Del Barrio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Zaragoza garcia <\/li>\n<li>eduardo Navarro garcia (vocal)<\/li>\n<li> Garcia vieitez Juan  Jos\u00e9 (vocal)<\/li>\n<li>alicia Rodr\u00edguez barbero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jarque Fuertes M\u00aa Jes\u00fas En este trabajo de tesis doctoral se estudian las respuestas vasculares inducidas por [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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