{"id":76360,"date":"2018-03-09T23:21:43","date_gmt":"2018-03-09T23:21:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/variaciones-en-el-fitness-del-vih-1-durante-la-terapia-antirretroviral\/"},"modified":"2018-03-09T23:21:43","modified_gmt":"2018-03-09T23:21:43","slug":"variaciones-en-el-fitness-del-vih-1-durante-la-terapia-antirretroviral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/variaciones-en-el-fitness-del-vih-1-durante-la-terapia-antirretroviral\/","title":{"rendered":"Variaciones en el \u00abfitness\u00bb del vih-1 durante la terapia antirretroviral"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Julia Garcia Prado <\/strong><\/h2>\n<p>El virus de inmunodeficiencia humana tipo-1 (vih-1) es el agente etiol\u00f3gico responsable del s\u00edndrome de inmunodeficiencia adquirida (sida). Esta enfermedad se caracteriza por una p\u00e9rdida sostenida de linfocitos t cd4+, provocando una alteraci\u00f3n global del sistema inmunitario, y dejando al individuo expuesto a infecciones oportunistas y al desarrollo de ciertas neoplasias.  desde la introducci\u00f3n de la zidovudina en el a\u00f1o 1986 hasta la implantaci\u00f3n a partir del a\u00f1o 1996 de las terapias antirretrovirales de gran actividad o targa (combinaciones de al menos tres compuestos antirretrovirales) se ha aprobado un total de 19 nuevos f\u00e1rmacos para el tratamiento de la infecci\u00f3n por el vih-1. En su conjunto, la quimioterapia contra la infecci\u00f3n por el vih-1 incrementa la esperanza de vida de los individuos infectados. sin embargo, complicaciones surgidas por el uso de estas terapias (p.E una adherencia sub\u00f3ptima, alteraciones en el perfil f\u00e1rmaco-cin\u00e9tico de algunos pacientes o la falta de potencia de los tratamientos) propician la selecci\u00f3n de mutaciones de resistencia frente a los f\u00e1rmacos antirretrovirales. la aparici\u00f3n de estas mutaciones en el genoma del vih-1 constituye una barrera al \u00e9xito duradero de las terapias antirretrovirales.  nuestras investigaciones parte del inter\u00e9s por el estudio de la variaci\u00f3n en la eficacia biol\u00f3gica o \u00abfitness\u00bb del vih-1 debido a la adquisici\u00f3n de mutaciones de resistencia. La relaci\u00f3n entre el mantenimiento de cepas virales con bajo \u00abfitness\u00bb y elevada resistencia con un posible beneficio cl\u00ednico constituye uno de los ejes centrales en los estudios aplicados de \u00abfitness\u00bb viral. A lo largo de este trabajo resumir\u00e9 el conocimiento acumulado en los \u00faltimos a\u00f1os en el estudio del vih-1: su estructura b\u00e1sica y aspectos m\u00e1s relacionadso con esta tesis, como son los fen\u00f3menos de resistencia a antirretrovirales y sus consecuencias en la modulaci\u00f3n del \u00abfitness\u00bb del vih-1.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Variaciones en el \u00abfitness\u00bb del vih-1 durante la terapia antirretroviral<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Variaciones en el \u00abfitness\u00bb del vih-1 durante la terapia antirretroviral <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Julia Garcia Prado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/09\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Javier Martinez Picado<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Santiago Guill\u00e9n moreno <\/li>\n<li>joan Jofre torroella (vocal)<\/li>\n<li> Bofil i soliger margarita (vocal)<\/li>\n<li>cecilio L\u00f3pez gal\u00edndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Julia Garcia Prado El virus de inmunodeficiencia humana tipo-1 (vih-1) es el agente etiol\u00f3gico responsable del s\u00edndrome [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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