{"id":76371,"date":"2018-03-09T23:21:43","date_gmt":"2018-03-09T23:21:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diseno-sintesis-y-evaluacion-biologica-de-n-fenilindoles-como-inhibidores-selectivos-de-la-ciclooxigenasa-2\/"},"modified":"2018-03-09T23:21:43","modified_gmt":"2018-03-09T23:21:43","slug":"diseno-sintesis-y-evaluacion-biologica-de-n-fenilindoles-como-inhibidores-selectivos-de-la-ciclooxigenasa-2","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica-organica\/diseno-sintesis-y-evaluacion-biologica-de-n-fenilindoles-como-inhibidores-selectivos-de-la-ciclooxigenasa-2\/","title":{"rendered":"Diseno, sintesis y evaluacion biologica de n-fenilindoles como inhibidores selectivos de la ciclooxigenasa 2"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Olga Cruz Lopez <\/strong><\/h2>\n<p>Desde el descubrimiento de la ciclooxigenasa hasta la aparici\u00f3n de una posible cox-4, se han identificado tres isoformas de la  enzima denominadas cox-1, cox-2 y cox-3. Los estudios realizados sobre las isoformas cox-1 y cox-2 han permitido profundizar en el conocimiento de su expresi\u00f3n g\u00e9nica, estructura y sus implicaciones en los distintos procesos fisiol\u00f3gicos y patol\u00f3gicos. Inicialmente se pens\u00f3 que la cox-1 estaba relacionada con efectos fisiol\u00f3gicos al contrario que la cox-2, cuya implicaci\u00f3n en distintos procesos patol\u00f3gicos la convert\u00eda en la diana perfecta para ser inhibida selectivamente. La obtenci\u00f3n de inhibidores selectivos de la cox-2 como agentes antiinflamatorios, analg\u00e9sicos y antipir\u00e9ticos, adem\u00e1s de como agentes eficaces en el tratamiento del c\u00e1ncer y la enfermedad de alzheimer, sin los efectos adversos caracter\u00edsticos de los aines cl\u00e1sicos, es el principal objetivo de numerosos investigadores e industrias farmac\u00e9uticas. En nuestro grupo de investigaci\u00f3n se llev\u00f3 a cabo la  sintesis de una<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Diseno, sintesis y evaluacion biologica de n-fenilindoles como inhibidores selectivos de la ciclooxigenasa 2<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Diseno, sintesis y evaluacion biologica de n-fenilindoles como inhibidores selectivos de la ciclooxigenasa 2 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Olga Cruz Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/09\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Espinosa \u00fabeda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Fernandez Brana <\/li>\n<li>Aurelio Orjales Venero (vocal)<\/li>\n<li>Juan  Manuel Duarte P\u00e9rez (vocal)<\/li>\n<li>Lourdes Santana Pen\u00edn (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Olga Cruz Lopez Desde el descubrimiento de la ciclooxigenasa hasta la aparici\u00f3n de una posible cox-4, se [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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