{"id":76385,"date":"2018-03-09T23:21:47","date_gmt":"2018-03-09T23:21:47","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/impacto-pronostico-de-las-celulas-tumorales-residuales-aisladas-en-sangre-periferica-en-cancer-de-mama-de-alto-riesgo\/"},"modified":"2018-03-09T23:21:47","modified_gmt":"2018-03-09T23:21:47","slug":"impacto-pronostico-de-las-celulas-tumorales-residuales-aisladas-en-sangre-periferica-en-cancer-de-mama-de-alto-riesgo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/impacto-pronostico-de-las-celulas-tumorales-residuales-aisladas-en-sangre-periferica-en-cancer-de-mama-de-alto-riesgo\/","title":{"rendered":"Impacto pron\u00f3stico de las c\u00e9lulas tumorales residuales aisladas en sangre perif\u00e9rica en c\u00e1ncer de mama de alto riesgo."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Miguel Quint\u00e9la Fandi\u00f1o <\/strong><\/h2>\n<p>Introducci\u00f3n: a pesar de la existencia de diversos estudios acerca del impacto pron\u00f3stico de la presencia de micromet\u00e1stasis en medula \u00f3sea (detectadas inmediatamente despu\u00e9s de la cirug\u00eda del tumor primario), la importancia del impacto de la presencia de micromet\u00e1stasis en sangre perif\u00e9rica no est\u00e1 completamente aclarada. La b\u00fasqueda de micromet\u00e1stasis ha de hacerse detectando diversos tr\u00e1nscritos expresados preferentemente en c\u00e9lulas tumorales mamarias y cuya expresi\u00f3n sea pr\u00e1cticamente nula en tejido hemopoy\u00e9tico. algunos estudios existentes se han hecho buscando tr\u00e1nscritos de ck-19 y\/o her-2. Nosotros hemos buscado las micromet\u00e1stasis buscando ck-19 y her-2, asi como tres tr\u00e1nscritos procedentes de un an\u00e1lisis seriado de expresi\u00f3n g\u00e9nica (sage) diferencial entre c\u00e1ncer de mama y tejido hemopoy\u00e9tico (pib; ps2 y egp2). Nuestro objetivo fue investigar el impacto pron\u00f3stico  de la presencia de micromet\u00e1stasis en sangre perif\u00e9rica (tras la quimioterapia adyuvante) en la supervivencia de pacientes con c\u00e1ncer de mama de alto riesgo. Pacientes y m\u00e9todos: entre 1993 y 2000,84 pacientes con cancer de mama de alto riesgo (edad mediana 42 a\u00f1os) (4-9 ganglios afectos 25% \/ mayor 10 ganglios 75%) fueron tratadas en nuestro centro con quimioterapia adyuvante (fec x 6  (82%) o ac-taxol (18%\u00bb\u00bb antes de ser sometidas a un ciclo de quimioterapia a altas dosis con soporte de progenitores hemopoy\u00e9ticos perif\u00e9ricos seg\u00fan el esquema stamp v. Posteriormente se administr\u00f3 radiolhormonoterapia seg\u00fan indicaci\u00f3n. Se congelaron al\u00edcuotas de c\u00e9lulas mononucleares procedentes de la af\u00e9resis realizada para la obtenci\u00f3n de precursores hemopoy\u00e9ticos.  el rnrna total de cada al\u00edcuota se aisl\u00f3 en un magna pure lc instrumenr, posteriormente se realiz\u00f3 una retrotranscripci\u00f3n a c- dna con hex\u00e1lneros al azar. Los tr\u00e1nscritos de k19, her-2, pib. Ps2 y egp2 se cuantificaron de modo relativo a la bglucuronidasa por pcr en tiempo<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Impacto pron\u00f3stico de las c\u00e9lulas tumorales residuales aisladas en sangre perif\u00e9rica en c\u00e1ncer de mama de alto riesgo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Impacto pron\u00f3stico de las c\u00e9lulas tumorales residuales aisladas en sangre perif\u00e9rica en c\u00e1ncer de mama de alto riesgo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Miguel Quint\u00e9la Fandi\u00f1o <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/09\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ricardo Hitt Sabag<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: hern\u00e1n Cort\u00e9s-funes castro <\/li>\n<li>Mar\u00eda Espa\u00f1a sanz (vocal)<\/li>\n<li> Fuente p\u00e9rez pedro de la (vocal)<\/li>\n<li>Jorge  augusto Quiroga vilas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Miguel Quint\u00e9la Fandi\u00f1o Introducci\u00f3n: a pesar de la existencia de diversos estudios acerca del impacto pron\u00f3stico de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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