{"id":76503,"date":"2005-01-10T00:00:00","date_gmt":"2005-01-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/polimorfismo-cyp2c19-en-el-riesgo-para-el-desarrollo-de-temblor-esencial\/"},"modified":"2005-01-10T00:00:00","modified_gmt":"2005-01-10T00:00:00","slug":"polimorfismo-cyp2c19-en-el-riesgo-para-el-desarrollo-de-temblor-esencial","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/neurologia\/polimorfismo-cyp2c19-en-el-riesgo-para-el-desarrollo-de-temblor-esencial\/","title":{"rendered":"Polimorfismo cyp2c19 en el riesgo para el desarrollo de temblor esencial"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Hortensia Alonso Navarro <\/strong><\/h2>\n<p>Objetivos: muchos pacientes con temblor esencial ( te), desarrollan efectos adversos a la primidona, un antiepil\u00e9ptico empleado en el tratamiento de dicha enfermedad. Hemos investigado la asociaci\u00f3n entre el polimorfismo cyp2c19 ( posiblemente relacionado al metabolismo de la primidona) y el riesgo para desarrollar temblor esencial y efectos adversos agudos a primidona. m\u00e9todos: se estudi\u00f3 el genotipo cyp2c19 y sus variantes al\u00e9licas en dna leucocitario de 200 pacientes con te y 300 controles sanos no relacionados entre s\u00ed. El an\u00e1lisis genot\u00edpico se realiz\u00f3 mediante pcr ( reacci\u00f3n de la polimerasa en cadena) y an\u00e1lisis de fragmentos de restricci\u00f3n. resultados: la frecuencia del genotipo cyp2c19 *1\/ cyp2c19 *2, y la variante al\u00e9lica cyp2c19 *2 fueron significativamente m\u00e1s frecuentes en pacientes con te comparados con controles ( p= 0.0044 y p= 0.0067, respectivamente). La frecuencia de metabolizadores pobres seg\u00fan genotipo fue  1% en pacientes con te y 1.3% en controles. La edad media de comienzo de te no difiri\u00f3 significativamente entre pacientes con genotipo cyp2c19 *1\/ cyp2c19 *2 y pacientes con genotipo cyp2c19 *1\/ cyp2c19 *1. Las frecuencias del genotipo cyp2c19 *1\/ cy2c19 *2 y la variante al\u00e9lica cyp2c19 *2 no difirieron significativamente entre pacientes con te con buena tolerancia a primidona y pacientes que desarrollaron efectos adversos y ambos comparados con controles. Las frecuencias del genotipo cyp2c19 *1\/ cyp2c19 *2 y la variante al\u00e9lica cyp2c19 *2 en pacientes con temblor vocal, cef\u00e1lico, lingual o mandibular no difirieron significativamente con los del grupo control. conclusi\u00f3n: estos resultados sugieren que la heterocigosis cyp2c19 *1\/ cyp2c19 *2 est\u00e1 asociada con el riesgo para desarrollar te aunque no tenga influencia en la edad de comienzo del temblor, la presentaci\u00f3n de efectos adversos agudos a primidona o la existencia de temblor cef\u00e1lico, vocal, lingual o mandibular<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Polimorfismo cyp2c19 en el riesgo para el desarrollo de temblor esencial<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Polimorfismo cyp2c19 en el riesgo para el desarrollo de temblor esencial <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Hortensia Alonso Navarro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/10\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Tomas Lopez Alburquerque<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: julio Moratinos <\/li>\n<li>Mar\u00eda  del rosario Martin gonzalez (vocal)<\/li>\n<li>pedro Garcia-ruiz espiga (vocal)<\/li>\n<li>Mar\u00eda  dolores estilita Lopez garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Hortensia Alonso Navarro Objetivos: muchos pacientes con temblor esencial ( te), desarrollan efectos adversos a la primidona, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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