{"id":76511,"date":"2005-03-10T00:00:00","date_gmt":"2005-03-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diseno-sa%c2%adntesis-y-aplicaciones-de-dendra%c2%admeros-basados-en-cadenas-de-poliprolina\/"},"modified":"2005-03-10T00:00:00","modified_gmt":"2005-03-10T00:00:00","slug":"diseno-sa%c2%adntesis-y-aplicaciones-de-dendra%c2%admeros-basados-en-cadenas-de-poliprolina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/diseno-sa%c2%adntesis-y-aplicaciones-de-dendra%c2%admeros-basados-en-cadenas-de-poliprolina\/","title":{"rendered":"Dise\u00f1o, s\u00edntesis y aplicaciones de dendr\u00edmeros basados en cadenas de poliprolina."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Sanclimens P\u00e9rez De Rozas Gl\u00f3ria <\/strong><\/h2>\n<p>El objetivo principal de la tesis se centra en el dise\u00f1o y s\u00edntesis de una familia dendr\u00edmeros basados en secuencia de poliprolina para su aplicaci\u00f3n en el campo m\u00e9dico como sistema de transporte y liberaci\u00f3n de f\u00e1rmacos. los dendr\u00edmeros son macromol\u00e9culas con una arquitectura similar a la de un \u00e1rbol. Los dendr\u00edmeros son t\u00edpicamente monodispersos, con un elevado n\u00famero de ramificaciones, geometr\u00eda fractal tridimensional, topolog\u00eda y tama\u00f1o definido. As\u00ed pues, sintetizar dendr\u00edmeros de poliprolina permite crear prote\u00ednas biomim\u00e9ticas, pol\u00edmeros solubles en agua y biodendr\u00edmeros en un \u00fanico compuesto.  despu\u00e9s de un estudio exhaustivo de la etapa de crecimiento para la s\u00edntesis de dendr\u00edmeros, se ha concluido que la s\u00edntesis \u00f3ptima se lleva a cabo mediante s\u00edntesis en fase s\u00f3lida conla incorporaci\u00f3n reiterada de bloques de construci\u00f3n ricos en prolina, adicionando gly en la posici\u00f3n n-terminal [(fmoc-gly-pro5)2-xxx-oh donde xxx=amp o imd], en resinas de baja funcionalizaci\u00f3n. la incorporaci\u00f3n de glicina en los bloques de construci\u00f3n es trascendental para la obtenci\u00f3n de los dendr\u00edmeros. Esta estrataeg\u00eda, adem\u00e1s, ofrece una amplia versatilidad para la preparaci\u00f3n de nuevos dendr\u00edmeros pept\u00eddicos en fase s\u00f3lida. Durante la s\u00edntesis de dendr\u00edmeros en fase s\u00f3lida se ha observado un efecto sobre las bolas de resina llamado saturaci\u00f3n o tensi\u00f3n de la resina (stress). Este fen\u00f3meno pone de manifiesto que la metodolog\u00eda sint\u00e9tica describa en la presente memoria es perfectamente viable para la s\u00edntesis de dendr\u00edmeros de poliprolina de segunda y tercera generaci\u00f3n. en cambio, para la s\u00edntesis de generaciones superiores alcanzar\u00eda su limite debido a la degradaci\u00f3n del soporte polim\u00e9rico. El an\u00e1lisis por dicro\u00edsmo circular concluye que los bloques de construcci\u00f3n ricos en prolina tienen plasticidad conformacional, adquiriendo tanto las estructuras de ppi y ppii. En cambio, los dendr\u00edmeros<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dise\u00f1o, s\u00edntesis y aplicaciones de dendr\u00edmeros basados en cadenas de poliprolina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dise\u00f1o, s\u00edntesis y aplicaciones de dendr\u00edmeros basados en cadenas de poliprolina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Sanclimens P\u00e9rez De Rozas Gl\u00f3ria <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/10\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miriam Royo Exp\u00f3sito<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Suau suarez <\/li>\n<li>jaume Veciana mir\u00f3 (vocal)<\/li>\n<li>angel Messeguer peypoch (vocal)<\/li>\n<li>Jes\u00fas Vicent m. (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sanclimens P\u00e9rez De Rozas Gl\u00f3ria El objetivo principal de la tesis se centra en el dise\u00f1o y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,396,17,966],"tags":[18986,1389,165061,1098,2512,165060],"class_list":["post-76511","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-polipeptidos-y-proteinas","category-quimica","category-quimica-macromolecular","tag-angel-messeguer-peypoch","tag-jaume-veciana-miro","tag-jesus-vicent-m","tag-miriam-royo-exposito","tag-rafael-suau-suarez","tag-sanclimens-perez-de-rozas-glaria"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/76511","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=76511"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/76511\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=76511"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=76511"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=76511"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}