{"id":76531,"date":"2005-04-10T00:00:00","date_gmt":"2005-04-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/haplotipos-geneticos-de-tnf-alfa-e-il-10-y-rechazo-agudo-del-injerto-cardiaco\/"},"modified":"2005-04-10T00:00:00","modified_gmt":"2005-04-10T00:00:00","slug":"haplotipos-geneticos-de-tnf-alfa-e-il-10-y-rechazo-agudo-del-injerto-cardiaco","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/haplotipos-geneticos-de-tnf-alfa-e-il-10-y-rechazo-agudo-del-injerto-cardiaco\/","title":{"rendered":"Haplotipos gen\u00e9ticos de tnf-alfa e il-10 y rechazo agudo del injerto cardiaco."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gutierrez Diez M. Cruz <\/strong><\/h2>\n<p>El rechazo agudo del coraz\u00f3n trasplantado es un proceso multifactorial complejo en el que intervienen tanto moduladores ambientales como moleculares. en la \u00faltima d\u00e9cada est\u00e1 adquiriendo una especial importancia las citoquinas las cuales dependen de genes polim\u00f3rficos. Las citoquinas son el c\u00f3digo de se\u00f1ales que sirven para trasmitir informaci\u00f3n de forma r\u00e1pida y directa entre las distintas c\u00e9lulas de la inflamaci\u00f3n, inmunidad y hematopoyesis, modulando as\u00ed la intensidad de la respuesta inflamatoria. Gran n\u00famero de publicaciones otorgan especial importancia al factor de necrosis tumoral (tnf-alfa) e interleuquina 10 (il-10).  la hip\u00f3tesis de este trabajo se basa en la consideraci\u00f3n de que ser portador de haplotipos tnf-alfa, relacionados con la sobreexpresi\u00f3n del mismo, en combinaci\u00f3n con haplotipos relacionados con la infraexpresi\u00f3n il-10, son alto factor de riesgo de rechazo agudo del injerto; mientras que en combinaci\u00f3n con sobreexpresi\u00f3n o expresi\u00f3n media de il-10 supone un riesgo moderado.  el estudio se ha realizado en poblaci\u00f3n relacionada directamente con el hospital universitario marqu\u00e9s de valdecilla que comprende 141 controles, donantes de sangre de este hospital, y 133 trasplantados cardiacos. Se han considerado como variables dependientes o susceptibles de controles, donantes de sangre de este hospital, y 133 trasplantados cardiacos. Se han considerado como variables dependientes o susceptibles de enfermedad, la manifestaci\u00f3n cl\u00ednica de rechazo agudo del injerto, y la cardiopat\u00eda isqu\u00e9mica como causa de necesidad del trasplante. Se han considerado como variables independientes o susceptibles de ser factor de riesgo, el ser portador de los haplotipos mencionados.  los resultados ponen de manifiesto que el an\u00e1lisis aislado del peso detnf-alfa no es relevante, sin embargo cuando se considera il-10 como factor modulador del perfil proinflamatorio de tnf-alfa, se demuestra que ser portador del perfil<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Haplotipos gen\u00e9ticos de tnf-alfa e il-10 y rechazo agudo del injerto cardiaco.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Haplotipos gen\u00e9ticos de tnf-alfa e il-10 y rechazo agudo del injerto cardiaco. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gutierrez Diez M. Cruz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/10\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Manuel Revuelta Soba<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Jose Fernando val bernal <\/li>\n<li>gabriel T\u00e9llez de peralta (vocal)<\/li>\n<li>Jos\u00e9 Luis Vallejo ruiz (vocal)<\/li>\n<li>ortega Alvaro castellanos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gutierrez Diez M. Cruz El rechazo agudo del coraz\u00f3n trasplantado es un proceso multifactorial complejo en el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[10518,155,35,9,141,962],"tags":[6148,165101,10583,24368,7944,165102],"class_list":["post-76531","post","type-post","status-publish","format-standard","hentry","category-cantabria","category-ciencias-clinicas","category-ciencias-de-la-vida","category-ciencias-medicas","category-cirugia","category-genetica","tag-gabriel-tellez-de-peralta","tag-gutierrez-diez-m-cruz","tag-jose-fernando-val-bernal","tag-jose-luis-vallejo-ruiz","tag-jose-manuel-revuelta-soba","tag-ortega-alvaro-castellanos"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/76531","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=76531"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/76531\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=76531"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=76531"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=76531"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}