{"id":76558,"date":"2005-06-10T00:00:00","date_gmt":"2005-06-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-canal-de-potasio-kv1-3-papel-fisiologico-y-biologa%c2%ada-del-complejo-funcional\/"},"modified":"2005-06-10T00:00:00","modified_gmt":"2005-06-10T00:00:00","slug":"el-canal-de-potasio-kv1-3-papel-fisiologico-y-biologa%c2%ada-del-complejo-funcional","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/el-canal-de-potasio-kv1-3-papel-fisiologico-y-biologa%c2%ada-del-complejo-funcional\/","title":{"rendered":"El canal de potasio kv1.3 papel fisiol\u00f3gico y biolog\u00eda del complejo funcional."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rub\u00e9n Vicente Garc\u00eda <\/strong><\/h2>\n<p>En esta tesis doctoral se presentan los estudios realizados sobre kv1.3, uno de los canales de potasio existentes en macr\u00f3fagos y su regulaci\u00f3n ante distintos est\u00edmulos de proliferaci\u00f3n y activaci\u00f3n celular.  en concreto, en la primera contribuci\u00f3n que se adjunta se describe c\u00f3mo los canales de potasio kv1.3, kv1.5 y kir2.1 son los responsables de las corrientes de salida dependiente de voltaje y de rectificaci\u00f3n de entrada que se detectan en estas c\u00e9lulas. En este trabajo se muestra c\u00f3mo  kv1.3 y kir2.1 est\u00e1n altamente regulados tanto por el factor de crecimiento mcsf, como por factores inductores de la activaci\u00f3n de los macr\u00f3fagos como son ellipopolisac\u00e1rido y la citoquina tnfa, existiendo cambios electrofisiol\u00f3gicos en la corriente kv. Estos estudios muestran c\u00f3mo, no s\u00f3lo kv1.3 se ve regulado en los procesos de proliferaci\u00f3n y activaci\u00f3n, sino que se requiere su participaci\u00f3n en estos procesos. Como complemento a esta regula(!I\u00f3n se adjunta un trabajo donde se muestra que esta modulaci\u00f3n es un mecanismo general que puede ser importante en diferentes patolog\u00edas sist\u00e9micas en las que estos mediadores est\u00e9n presentes como caquexia, sepsis o inflamaci\u00f3n cr\u00f3nica.  por otro lado, un segundo apartado en esta tesis doctoral se centra en los cambios electrofisiol\u00f3gicos que presentan en la kv en proliferaci\u00f3n y activaci\u00f3n. Se analiza la posibilidad de que sean debidos a cambios en la composici\u00f3n del complejo funcional.En este sentido se presenta una contribuci\u00f3n donde se describe la presencia en macr\u00f3fagos de todas las subunidades kv\u00c2\u00a13 estudiadas menos la kv\u00c2\u00a134. La proliferaci\u00f3n inducida por mcsf incrementar\u00eda la expresi\u00f3n de todas las subunidades auxiliares mientras que distintos est\u00edmulos de activaci\u00f3n, lps y tnfa, regulan la expresi\u00f3n g\u00e9nica di estas prote\u00ednas de distinta forma. Los par\u00e1metros cin\u00e9ticos de la corriente de salida de potasio sobre los que estas subunidades act\u00faan, como son las c<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El canal de potasio kv1.3 papel fisiol\u00f3gico y biolog\u00eda del complejo funcional.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El canal de potasio kv1.3 papel fisiol\u00f3gico y biolog\u00eda del complejo funcional. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rub\u00e9n Vicente Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/10\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Felipe Campo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: carles (secretario) Solsona sancho <\/li>\n<li>Miguel \u00e1ngel Valverde de castro (vocal)<\/li>\n<li>carmen Valenzuela miranda (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rub\u00e9n Vicente Garc\u00eda En esta tesis doctoral se presentan los estudios realizados sobre kv1.3, uno de los 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