{"id":76592,"date":"2005-07-10T00:00:00","date_gmt":"2005-07-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/celulas-stem-y-cancer-humano-el-programa-genetico-de-las-celulas-stem-en-un-modelo-de-raton-para-bcl6\/"},"modified":"2005-07-10T00:00:00","modified_gmt":"2005-07-10T00:00:00","slug":"celulas-stem-y-cancer-humano-el-programa-genetico-de-las-celulas-stem-en-un-modelo-de-raton-para-bcl6","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia-clinica\/celulas-stem-y-cancer-humano-el-programa-genetico-de-las-celulas-stem-en-un-modelo-de-raton-para-bcl6\/","title":{"rendered":"Celulas stem y cancer humano. el programa genetico de las celulas stem en un modelo de raton para bcl6"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Perez Caro M\u00aa Jes\u00fas <\/strong><\/h2>\n<p>El linfoma de c\u00e9lula grande difuso (dlbcl) es el m\u00e1s com\u00fan entre los linfomas adultos, el 40% de los linfomas no hodgkin son dlbcl, y causante de unos 30000 nuevos casos cada a\u00f1o, aproximadamente. A pesar de que el dlbcl es una de las enfermedades humanas m\u00e1s sensibles a la quimioterapia, muchos de los nuevos pacientes diagnosticados no ser\u00e1n curados con la quimioterapia convencional basada en la antraciclina. Los recientes descubrimientos que determinan el papel cr\u00edtico de los eventos g\u00e9nicos en el seno de la c\u00e9lula stem en algunos c\u00e1nceres humanos han generado un gran entusiasmo dentro de la comunidad cient\u00edfica a la hora de llevar a cabo la generaci\u00f3n de modelos de rat\u00f3n que reflejen con exactitud la correlaci\u00f3n de genotipo-fenotipo en el c\u00e1ncer humano, importante para entender y tratar el proceso de desarrollo de la enfermedad humana. En este trabajo presentamos la extrapolaci\u00f3n de esta correlaci\u00f3n genotipo-fenotipo del c\u00e1ncer humano en un modelo animal de rat\u00f3n generado mediante la direcci\u00f3n espec\u00edfica del oncog\u00e9n bcl6 a las c\u00e9lulas som\u00e1ticas stem. Estos ratones reproducen la patolog\u00eda humana del dlbcl indicando que el oncog\u00e9n bcl6 dirige un programa gen\u00e9tico espec\u00edfico que enlaza a las c\u00e9lulas stem con la patog\u00e9nesis del dlbcl humano.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Celulas stem y cancer humano. el programa genetico de las celulas stem en un modelo de raton para bcl6<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Celulas stem y cancer humano. el programa genetico de las celulas stem en un modelo de raton para bcl6 <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Perez Caro M\u00aa Jes\u00fas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/10\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isidro Javier S\u00e1nchez Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel angel Piris pinilla <\/li>\n<li>cayetano Gonz\u00e1lez hern\u00e1ndez (vocal)<\/li>\n<li>jauma Piucats xanco (vocal)<\/li>\n<li>Miguel Torres (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Perez Caro M\u00aa Jes\u00fas El linfoma de c\u00e9lula grande difuso (dlbcl) es el m\u00e1s com\u00fan entre los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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