{"id":76655,"date":"2018-03-09T23:22:03","date_gmt":"2018-03-09T23:22:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/marcadores-moleculares-en-tumores-de-celulas-germinales-valor-pronostico-e-implicaciones-terapeuticas\/"},"modified":"2018-03-09T23:22:03","modified_gmt":"2018-03-09T23:22:03","slug":"marcadores-moleculares-en-tumores-de-celulas-germinales-valor-pronostico-e-implicaciones-terapeuticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/marcadores-moleculares-en-tumores-de-celulas-germinales-valor-pronostico-e-implicaciones-terapeuticas\/","title":{"rendered":"Marcadores moleculares en tumores de celulas germinales: valor pron\u00f3stico e implicaciones terap\u00e9uticas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ignacio Duran Martinez <\/strong><\/h2>\n<p>Introducci\u00f3n     los tumores de c\u00e9lulas germinales (tcgs) conforman un grupo de neoplasias caracterizado por su extraordinaria sensibilidad a la quimioterapia basada en cisplatino. Sin embargo, un 20-30% de los pacientes no lograr\u00e1n una remisi\u00f3n completa o presentar\u00e1n una recidiva a lo largo del curso de la enfermedad. Con el fin de identificar a estos pacientes disponemos de varios factores pron\u00f3sticos como son los valores s\u00e9ricos de determinados marcadores tumorales (afp y betahgc), el nivel s\u00e9rico de la ldh y la localizaci\u00f3n del tumor primario y sus met\u00e1stasis. Estos factores nos han permitido establecer una clasificaci\u00f3n pron\u00f3stica que estratifica a los pacientes en diferentes grupos de riesgo. A pesar de la validez de esta clasificaci\u00f3n, serie deseable identificar nuevos factores pron\u00f3sticos y\/o predictivos de \u00edndole molecular que seleccionaran aquellos pacientes que fueran a tener un curso refractario, con una peor respuesta a los tratamientos habitualmente eficaces, o incluso que pudieran ser candidatos a terapias dirigidas contra dianas moleculares espec\u00edficas.  material y m\u00e9todos     se han analizado 109 muestras histol\u00f3gicas de 84 pacientes para establecer su perfil molecular, valorando la expresi\u00f3n de egfr, erb-b2 y kit mediante t\u00e9cnicas de inmunohistoqu\u00edmica. Asimismo se ha procedido a estudiar la correlaci\u00f3n del grado de expresi\u00f3n de dichos marcadores moleculares son factores pron\u00f3sticos ya establecidos, respuesta al tratamiento, supervivencia libre de enfermedad (sle) y supervivencia global (sg).  resutlados     el 28% de los tumores mostraron sobreexpresi\u00f3n de egfr, siendo la variante coriocarcinoma la que presento dicho hallazgo con mayor frecuencia (86%) y los tumores seminomatosos los que mas raramente (7%). La expresi\u00f3n de erb-b2 fue muy escasa [13% de las biopasias] apareciendo casi exclusivamente en tumores no seminomatosos. El 49% de las muestras mostraron sobreexpresi\u00f3n de kit, siendo esta m\u00e1s frecuente en<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Marcadores moleculares en tumores de celulas germinales: valor pron\u00f3stico e implicaciones terap\u00e9uticas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Marcadores moleculares en tumores de celulas germinales: valor pron\u00f3stico e implicaciones terap\u00e9uticas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ignacio Duran Martinez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/10\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>ares Rodr\u00edguez Paz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Millan nu\u00f1ez cortes <\/li>\n<li>julio Rifa ferrer (vocal)<\/li>\n<li>Manuel G\u00f3nzalez bar\u00f3n (vocal)<\/li>\n<li>julio De la morena fern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ignacio Duran Martinez Introducci\u00f3n los tumores de c\u00e9lulas germinales (tcgs) conforman un grupo de neoplasias caracterizado por [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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