{"id":76674,"date":"2018-03-09T23:22:03","date_gmt":"2018-03-09T23:22:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/lingandos-dimericos-y-gpcr-un-nuevo-concepto-terapeutico-con-farmacos-existentes\/"},"modified":"2018-03-09T23:22:03","modified_gmt":"2018-03-09T23:22:03","slug":"lingandos-dimericos-y-gpcr-un-nuevo-concepto-terapeutico-con-farmacos-existentes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/lingandos-dimericos-y-gpcr-un-nuevo-concepto-terapeutico-con-farmacos-existentes\/","title":{"rendered":"Lingandos dim\u00e9ricos y gpcr: un nuevo concepto terap\u00e9utico con f\u00e1rmacos existentes"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ruben Ventura Masip <\/strong><\/h2>\n<p>El objetivo principal de la tesis se centra en la s\u00edntesis de una familia de pol\u00edmeros basados en el polietilenglicol, en los cuales se ha unido mol\u00e9culas bioactivas en sus extremos, para su aplicaci\u00f3n en el campo m\u00e9dico. estos pol\u00edmeros debido a que presentan dos puntos bioactivos se llaman ligandos dim\u00e9ricos. Los pol\u00edmeros comerciales son t\u00edpicamente polidispersos, as\u00ed pues se ha desarrollado  una metodolog\u00eda que ha permitido la s\u00ednteis de pol\u00edmeros en fase s\u00f3lida de manera controlada y conseguir as\u00ed pol\u00edmeros de tama\u00f1o definido. Se opt\u00f3 por pol\u00edmeros tipo polietilenglicol, y en concreto poliamida-polietilenglicol, debido a su buena biocompatibilidad. En concreto se han unido mol\u00e9culas afines conlos receptores de adenosina y de dopamina, receptores que se encuentran involucrados en la enfermedad del parkinson. adem\u00e1s, se conoce que \u00e9stos receptores como puede ser el parkinson.  as\u00ed, se ha desarrollado una metodolog\u00eda sint\u00e9tica para un antagonista de adenosina de gran afinidad por el receptor, el xac, as\u00ed como para un agonista del receptor de dopamina, el ppht. Una vez seha dispuesto de \u00e9stos productos de cantidades suficientes, se han explorado sus estructuras para poderias modificar e introducir en los ligandos dim\u00e9ricos, es decir derivatizarlas con pol\u00edmros. Para \u00e9ste estudio, se han sintetizado dos quimiotecas de compuestos, de 23 y 16  compuestos respectivamente, y los ensayos bioqu\u00edmicos nos han relevado dos mol\u00e9culas que nos permiten sintetizar los ligandos dim\u00e9ricos sin que \u00e9stas biomol\u00e9culas pierdan afinidad con sus respectivos receptores.  una vez se dispuso de la estrategia sint\u00e9tica de pol\u00edmeros en fase s\u00f3lida, y de la manera de unir las biomol\u00e9culas a este pol\u00edmero, se pas\u00f3 a la s\u00edntesis de los ligandos dim\u00e9ricos, sintetizando compuestos de hasta 7 tallas polim\u00e9ricas diferentes. Se sintetizaron tambi\u00e9n los mon\u00f3meros de los ligandos, para poder estudiar el efecto del pol\u00edmero en<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Lingandos dim\u00e9ricos y gpcr: un nuevo concepto terap\u00e9utico con f\u00e1rmacos existentes<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Lingandos dim\u00e9ricos y gpcr: un nuevo concepto terap\u00e9utico con f\u00e1rmacos existentes <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ruben Ventura Masip <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/10\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miriam Royo Exp\u00f3sito<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ernest Giralt lledo <\/li>\n<li>Jos\u00e9 Luis Mascare\u00f1as cid (vocal)<\/li>\n<li>david Andreu mart\u00ednez (vocal)<\/li>\n<li>enrique Perez paya (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ruben Ventura Masip El objetivo principal de la tesis se centra en la s\u00edntesis de una familia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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