{"id":76717,"date":"2018-03-09T23:22:07","date_gmt":"2018-03-09T23:22:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/recombinacion-genetica-en-vih-1-patrones-de-recombinacion-y-relaciones-filogeneticas-en-formas-recombinantes-bf-y-bg-mediante-secuenciacion-completa-del-genoma\/"},"modified":"2018-03-09T23:22:07","modified_gmt":"2018-03-09T23:22:07","slug":"recombinacion-genetica-en-vih-1-patrones-de-recombinacion-y-relaciones-filogeneticas-en-formas-recombinantes-bf-y-bg-mediante-secuenciacion-completa-del-genoma","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/recombinacion-genetica-en-vih-1-patrones-de-recombinacion-y-relaciones-filogeneticas-en-formas-recombinantes-bf-y-bg-mediante-secuenciacion-completa-del-genoma\/","title":{"rendered":"Recombinaci\u00f3n gen\u00e9tica en vih-1: patrones de recombinaci\u00f3n y relaciones filogen\u00e9ticas en formas recombinantes bf y bg mediante secuenciacion completa del genoma"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Sierra Garc\u00eda <\/strong><\/h2>\n<p>El sida est\u00e1 causado por dos retrovirus pertenecientes a la subfamilia de los lentivirus, el vih-1 y el vih-2, de los cuales el vih-1 presenta distribuci\u00f3n mundial. El viri\u00f3n del vih-1 contiene dos copias de arn gen\u00f3mico asociadas a prote\u00ednas virales y rodeadas de una c\u00e1pside y de una envuelta lip\u00eddica en la que se insertan glicoprote\u00ednas virales y de la c\u00e9lula hu\u00e9sped. La elevada variabilidad que presenta el vih-1 se debe a la conjunci\u00f3n de diversos factores donde se puede resaltar la alta frecuencia de recombinaci\u00f3n, que constituye una parte intr\u00ednseca del ciclo replicativo de los retrovirus debido a que cada viri\u00f3n contiene dos genomas virales que pueden servir alternativamente de molde para la ti durante la s\u00edntesis del adn proviral. Su importancia en la pandemia de vih-1 se aprecia cada vez m\u00e1s con la creciente detecci\u00f3n de formas recombinantes en m\u00faltiples \u00e1reas geogr\u00e1ficas. Se han definido nueve subtipos dentro del grupo m del vih-1, cada uno de ellos tiene una distribuci\u00f3n geogr\u00e1fica caracter\u00edstica, aunque todos, excepto el b, se encuentran representados en \u00e1frica central. En \u00e1reas donde circulan diferentes subtipos del vih-1, se pueden originar formas recombinantes intersubtipo en individuos infectados por dos o m\u00e1s virus de distinto subtipo, que se convierten en circulantes cuando se a\u00edslan en tres individuos diferentes sin relaci\u00f3n epidemiol\u00f3gica (crfs).     teniendo en cuenta las implicaciones de la diversidad gen\u00e9tica del vih-1 en general, y de la recombinaci\u00f3n en particular, los objetivos que se plantean en esta tesis doctoral son los siguientes:     1,- an\u00e1lisis de las estructuras en mosaico de los genomas de virus recombinantes intersubtipo bf de sudam\u00e9rica (o de origen sudamericano) y bg de cuba.     2,- estudio de las posibles relaciones filogen\u00e9ticas entre ellos y con otros recombinantes descritos en al literatura.     3,- identificaci\u00f3n de nuevas formas reconviertes circulantes.     4,- estudio de la d<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Recombinaci\u00f3n gen\u00e9tica en vih-1: patrones de recombinaci\u00f3n y relaciones filogen\u00e9ticas en formas recombinantes bf y bg mediante secuenciacion completa del genoma<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Recombinaci\u00f3n gen\u00e9tica en vih-1: patrones de recombinaci\u00f3n y relaciones filogen\u00e9ticas en formas recombinantes bf y bg mediante secuenciacion completa del genoma <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Sierra Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/10\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Najera  Morrondo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Prieto prieto <\/li>\n<li>Antonio Ocampo hermida (vocal)<\/li>\n<li>esteban Domingo solans (vocal)<\/li>\n<li>ascensi\u00f3n Bernal zamora (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Sierra Garc\u00eda El sida est\u00e1 causado por dos retrovirus pertenecientes a la subfamilia de los lentivirus, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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