{"id":76790,"date":"2018-03-09T23:22:11","date_gmt":"2018-03-09T23:22:11","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/moleculas-implicadas-en-transmision-de-senales-en-linfocitos-t-y-celulas-dendra%c2%adticas-humanas\/"},"modified":"2018-03-09T23:22:11","modified_gmt":"2018-03-09T23:22:11","slug":"moleculas-implicadas-en-transmision-de-senales-en-linfocitos-t-y-celulas-dendra%c2%adticas-humanas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/moleculas-implicadas-en-transmision-de-senales-en-linfocitos-t-y-celulas-dendra%c2%adticas-humanas\/","title":{"rendered":"Mol\u00e9culas implicadas en transmisi\u00f3n de se\u00f1ales en linfocitos t y c\u00e9lulas dendr\u00edticas humanas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Esther Caparr\u00f3s Cayuela <\/strong><\/h2>\n<p>En la presente tesis se ha estudiado el mecanismo de regulaci\u00f3n de poblaciones t cd4+ y t cd8+ por distintos receptores, tanto en linfocitos t citot\u00f3xicos como en c\u00e9lulas dendr\u00edticas humanas. Por un lado, el estudio de la coagregaci\u00f3n en membrana del heterod\u00edmero activador cd94\/nkg2h y la mol\u00e9cula mhc-i en linfocitos t citot\u00f3xicos indic\u00f3 que se produce un bloqueo de distintas v\u00edas de activaci\u00f3n, as\u00ed como de la movilizaci\u00f3n del centro organizador de microt\u00fabulos a la zona de contacto entre la c\u00e9lula t efectora y la potencial c\u00e9lula diana. Biol\u00f3gicamente, el reconocimiento de receptores implicados en inhibici\u00f3n de la actividad citot\u00f3xica en linfocitos t cd8+ por ligandos presentes en c\u00e9lulas presentadoras de ant\u00edgeno permitir\u00eda un bloqueo de la lisis de estas c\u00e9lulas por parte de c\u00e9lulas citot\u00f3xicas.  por otra parte, estudiamos los mecanismos de transmisi\u00f3n de se\u00f1ales que se derivan de laligaci\u00f3n en membrana de la mol\u00e9cula cd70,. La agregaci\u00f3n de esta prote\u00edna transmembrana tipo ii induce activaci\u00f3n de erk mapk, as\u00ed como de akt y del factor de transcripci\u00f3n nfkb, adem\u00e1s de activar citotoxicidad en linfocitos t cd8 y cd4+. El an\u00e1lisis de los mutantes de la prote\u00edna generados en el laboratorio revel\u00f3 la importancia de la cys 17 y las ser 6 y 9 de la mol\u00e9cula en la inducci\u00f3n del factor de transcripci\u00f3n nf-kb y supervivencia.  finalmente, analizamos las consecuencias de la agregaci\u00f3n en membrana de la mol\u00e9cula dc-sign en c\u00e9lulas dendr\u00edticas derivadas de monocitos. Dc-sign es una lectina tipo c propia de c\u00e9lulas dendr\u00edticas inmaduras. Est\u00e1 relacionada con la interacci\u00f3n con distintos pat\u00f3genos que inducen infecciones cr\u00f3nicas, como citomegalovirus, aspergillus fumigatus, hiv o el virus del \u00e9bola. la activaci\u00f3n de dc-sign por sus ligandos induce una activaci\u00f3n de erk mapk y akt y movilizaci\u00f3n de calcio intracelula l incluso, esta mol\u00e9cula se localiza en balsas lip\u00eddicas e interacciona con o<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mol\u00e9culas implicadas en transmisi\u00f3n de se\u00f1ales en linfocitos t y c\u00e9lulas dendr\u00edticas humanas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mol\u00e9culas implicadas en transmisi\u00f3n de se\u00f1ales en linfocitos t y c\u00e9lulas dendr\u00edticas humanas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Esther Caparr\u00f3s Cayuela <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/10\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Aparicio Alonso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: gonzalo Rubio pedraza <\/li>\n<li>Jos\u00e9 Luis Rodriguez fernandez (vocal)<\/li>\n<li>Jos\u00e9 Yelamos lopez (vocal)<\/li>\n<li>Francisco Jos\u00e9 Garc\u00eda c\u00f3zar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Esther Caparr\u00f3s Cayuela En la presente tesis se ha estudiado el mecanismo de regulaci\u00f3n de poblaciones t [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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