{"id":76792,"date":"2018-03-09T23:22:11","date_gmt":"2018-03-09T23:22:11","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevas-aplicaciones-de-la-electroforesis-capilar-para-la-determinacion-de-compuestos-de-interes-farmacologico-y-metabolitos\/"},"modified":"2018-03-09T23:22:11","modified_gmt":"2018-03-09T23:22:11","slug":"nuevas-aplicaciones-de-la-electroforesis-capilar-para-la-determinacion-de-compuestos-de-interes-farmacologico-y-metabolitos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/nuevas-aplicaciones-de-la-electroforesis-capilar-para-la-determinacion-de-compuestos-de-interes-farmacologico-y-metabolitos\/","title":{"rendered":"Nuevas aplicaciones de la electroforesis capilar para la determinaci\u00f3n de compuestos de inter\u00e9s farmacol\u00f3gico y metabolitos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Raquel Galera Garc\u00eda <\/strong><\/h2>\n<p>En esta tesis se aportan nuevos m\u00e9todos anal\u00edticos para la determinaci\u00f3n de sustancias de inter\u00e9s terap\u00e9utico y de metabolitos empleando la t\u00e9cnica de electroforesis capilar. Adem\u00e1s, se demuestra la aplicabilidad de los m\u00e9todos propuestos para el control de los analitos seleccionados en diferentes tipos de muestras, tales como productos farmac\u00e9uticos comerciales y fluidos biol\u00f3gicos, consigui\u00e9ndose rapidez en los an\u00e1lisis y una excelente reproducibilidad en los resultados. Se han seleccionado como t\u00e9cnicas de detecci\u00f3n, dependiendo de las caracter\u00edsticas de los analitos, la espectrofotometr\u00eda o la fluorescencia inducida por l\u00e1ser, de gran sensibilidad.  utilizando la detecci\u00f3n espectrofotom\u00e9trica se han separado y determinado con excelentes resultados los antagonistas del receptor h2 de la histamina, ranitidina y famotidina. Tambi\u00e9n se ha conseguido una eficiente separaci\u00f3n por electroforesis capilar de alopurinol y su metabolito oxipurinol, especies inhibidoras de la xantina oxidasa que act\u00faan eficientemente en el tratamiento de la gota. En otras investigaciones de esta tesis se ha prestado atenci\u00f3n a la determinaci\u00f3n de productos de descomposici\u00f3n de drogas de inter\u00e9s. as\u00ed, se ha propuesto un m\u00e9todo de electroforesis capilar en zona libre para la separaci\u00f3n y determinaci\u00f3n del analg\u00e9sico y antipir\u00e9tico acetaminof\u00e9n y su producto de degradaci\u00f3n, el p-aminofenol, aportando un procedimiento mucho m\u00e1s fiable y sencillo que los encontrados en la bibliograf\u00eda. Otro problema que hemos abordado ha sido la separaci\u00f3n y determinaci\u00f3n de creatinina, uno de los marcadores cl\u00ednicos de m\u00e1s inter\u00e9s fundamentalmente en enfermos renales, en presencia de otras sustancias que pueden actuar como potenciales interferentes, tales como creatina, \u00e1cido \u00farico y \u00e1cido p-aminohip\u00farico. la cromatograf\u00eda capilar electrocin\u00e9tica micelar ha sido el modo m\u00e1s eficaz para separar el omeprazol, un potente inhibidor de la secr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevas aplicaciones de la electroforesis capilar para la determinaci\u00f3n de compuestos de inter\u00e9s farmacol\u00f3gico y metabolitos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevas aplicaciones de la electroforesis capilar para la determinaci\u00f3n de compuestos de inter\u00e9s farmacol\u00f3gico y metabolitos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Raquel Galera Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/10\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Mart\u00ednez Lozano Mar\u00eda  Del Carmen<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  S\u00e1nchez pedre\u00f1o mart\u00ednez concepci\u00f3n <\/li>\n<li> Murillo pulgar\u00edn Jos\u00e9 Antonio (vocal)<\/li>\n<li>agustin Garcia asuero (vocal)<\/li>\n<li>Jos\u00e9 Luis Hidalgo hidalgo de cisneros (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Raquel Galera Garc\u00eda En esta tesis se aportan nuevos m\u00e9todos anal\u00edticos para la determinaci\u00f3n de sustancias de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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