{"id":76912,"date":"2018-03-09T23:22:20","date_gmt":"2018-03-09T23:22:20","guid":{"rendered":""},"modified":"2018-03-09T23:22:20","modified_gmt":"2018-03-09T23:22:20","slug":"rasgos-clinicos-y-factores-predictivos-de-uveitis-en-sujetos-con-artritis-psoriasica-influencia-del-sexo-del-antigeno-hla-b27-y-de-los-alelos-hla-dr-en-la-expresion-fenotipica-de-la-espondiloartropa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/rasgos-clinicos-y-factores-predictivos-de-uveitis-en-sujetos-con-artritis-psoriasica-influencia-del-sexo-del-antigeno-hla-b27-y-de-los-alelos-hla-dr-en-la-expresion-fenotipica-de-la-espondiloartropa\/","title":{"rendered":"Rasgos clinicos y factores predictivos de uveitis en sujetos con artritis psoriasica. influencia del sexo, del antigeno hla b27 y de los alelos hla dr en la expresion fenotipica de la espondiloartropatia psoriasica"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Queiro Silva Manuel Ruben <\/strong><\/h2>\n<p>En la presente tesis se han estudiado cuatro aspectos, concernientes a la artritis psori\u00e1sica (ap), hasta ahora pobremente abordados en la literatura, a saber: factores cl\u00ednicos y predictivos de uveitis, influencia del sexo en la expresividad cl\u00ednica de la enfermedad, relaci\u00f3n de susceptibilidad e importancia fenot\u00edpica del ant\u00edgeno hla-b27, importancia de los ant\u00edgenos hla-dr en el riesgo de enfermedad y su influjo sobre la clasificaci\u00f3n de la misma en subgrupos.  los principales resultados de esta investigaci\u00f3n fueron: en la ap se observan dos variantes de uveitis, una similar a la uveitis anterior aguda de la espondilitis anquilosante (ea) y otra forma que tiende a la bilateralidad, cronicidad y afectaci\u00f3n del polo posterior. Los elementos que predicen esta complicaci\u00f3n son sacroileitis bilateral (or 17, 95% ic: 3.7-76, p= 0.0002), sindesmofitos (or 9.7, 95% ic: 0.97-97, p= 0.05) y el hla-dr13 (or 24, 95% ic: 3.78-150, p= 0.0056). Hla-b27 se asocia a la ap s\u00f3lo en varones (p= 0.002), mientras que en mujeres se aprecia m\u00e1s afecci\u00f3n perif\u00e9rica (p= 0.002) y erosiones radiol\u00f3gicas (p= 0.05). En sujetos hla-b27 (+) la enfermedad cut\u00e1nea (p= 0.028) y articular (p= 0.006) es m\u00e1s precoz que en los b27 (-). Hla-dr7 se asocia a oligoartritis (or 6, 95% ic: 2-15, pc= 0.001), mientras hla-dr8 se asocia a formas poliarticulares de ap (or 9.5, 95% ic: 2-42, pc= 0.003).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Rasgos clinicos y factores predictivos de uveitis en sujetos con artritis psoriasica. influencia del sexo, del antigeno hla b27 y de los alelos hla dr en la expresion fenotipica de la espondiloartropatia psoriasica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Rasgos clinicos y factores predictivos de uveitis en sujetos con artritis psoriasica. influencia del sexo, del antigeno hla b27 y de los alelos hla dr en la expresion fenotipica de la espondiloartropatia psoriasica <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Queiro Silva Manuel Ruben <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/10\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Torre Alonso Juan  Carlos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Lopez arranz y arranz Juan  sebastian <\/li>\n<li>Francisco Javier De toro santos (vocal)<\/li>\n<li>amado Rodriguez perez (vocal)<\/li>\n<li>eduardo Collantes estevez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Queiro Silva Manuel Ruben En la presente tesis se han estudiado cuatro aspectos, concernientes a la artritis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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