{"id":77027,"date":"2005-04-11T00:00:00","date_gmt":"2005-04-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-de-la-inhibicion-selectiva-de-la-ciclo-oxigenasa-2-en-la-prevencion-de-tumores-colorrectales-farmacologicamente-inducidos\/"},"modified":"2005-04-11T00:00:00","modified_gmt":"2005-04-11T00:00:00","slug":"influencia-de-la-inhibicion-selectiva-de-la-ciclo-oxigenasa-2-en-la-prevencion-de-tumores-colorrectales-farmacologicamente-inducidos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/influencia-de-la-inhibicion-selectiva-de-la-ciclo-oxigenasa-2-en-la-prevencion-de-tumores-colorrectales-farmacologicamente-inducidos\/","title":{"rendered":"Influencia de la inhibici\u00f3n selectiva de la ciclo-oxigenasa 2 en la prevenci\u00f3n de tumores colorrectales farmacol\u00f3gicamente inducidos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> \u00e1ngel Plaza Mart\u00ednez <\/strong><\/h2>\n<p>Introducci\u00f3n  los f\u00e1rmacos anti-inflamatorios no esteroideos y m\u00e1s recientemente los inhibidores selectivos de la ciclo-oxigenasa 2 (cox-2), parecen tener una mayor actividad anti-inflamatoria y anti-tumoral frente al desarrollo del c\u00e1ncer colorrectal.  objetivos  investigar el efecto de la inhibici\u00f3n selectiva de la cox-2 en la disminuci\u00f3n de la cantidad de tumores c\u00f3licos inducidos, as\u00ed como en la actividad cox-2 expresada en el tejido tumoral y valorar si este efecto es mayor que el conseguido con la inhibici\u00f3n no selectiva de la cox.  material y m\u00e9todos  se ha dise\u00f1ado un estudio prospectivo, aleatorizado y doble ciego sobre un modelo animal constituido por 35 ratas sprague-dawley macho de 225 gramos de peso medio (intervalo de 155 a 400 g), asignadas aleatoriamente a uno de los cuatro grupos siguientes: un grupo control (n=5) sin manipulaci\u00f3n experimental, un grupo de carcinog\u00e9nesis farmacol\u00f3gica (n=10) con inducci\u00f3n y promoci\u00f3n cancer\u00edgena c\u00f3lica con 1,2-dimetilhidrazina dihidrocloruro (1,2-dmh) (grupo dmh), un grupo de carcinog\u00e9nesis e inhibici\u00f3n no selectiva de la cox (n=10) (grupo dmh + aas) con administraci\u00f3n de \u00e1cido acetil-salic\u00edlico (aas) al tiempo de la carcinog\u00e9nesis farmacol\u00f3gica, y un grupo de carcinog\u00e9nesis e inhibici\u00f3n selectiva de la cox-2 (n=10) (grupo dmh + rfc), con administraci\u00f3n de rofecoxib (rfc) junto a la carcinog\u00e9nesis farmacol\u00f3gica. La inducci\u00f3n carcinog\u00e9nica se realiz\u00f3 con 1,2-dmh a dosis semanal de 25 mg \/ kg de peso durante 18 semanas por v\u00eda subcut\u00e1nea. Los antiinflamatorios se administraron por v\u00eda oral a raz\u00f3n de aas 30 mg \/ kg de peso del animal \/ d\u00eda y rofecoxib 3 mg \/ kg \/ d\u00eda, disueltos en el agua de consumo. Se analizaron los tumores c\u00f3licos inducidos en la semana 20 del inicio de la manipulaci\u00f3n experimental, con estudios microsc\u00f3picos e inmunohistoqu\u00edmicos.  resultados  se han obtenido 57 tumores, 27 adenomas y 30 adenocarcinomas, sin diferencias<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia de la inhibici\u00f3n selectiva de la ciclo-oxigenasa 2 en la prevenci\u00f3n de tumores colorrectales farmacol\u00f3gicamente inducidos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia de la inhibici\u00f3n selectiva de la ciclo-oxigenasa 2 en la prevenci\u00f3n de tumores colorrectales farmacol\u00f3gicamente inducidos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 \u00e1ngel Plaza Mart\u00ednez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/11\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Carbonell Cant\u00ed \/ Noguera Aguilar  Carlos \/ Jos\u00e9 Francisco<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: adolfo Benages Martinez <\/li>\n<li>eduardo Garcia granero ximenez (vocal)<\/li>\n<li> Soria cogollos  teresa    (ausente ) (vocal)<\/li>\n<li>Antonio Compa\u00f1 rosique (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de \u00e1ngel Plaza Mart\u00ednez Introducci\u00f3n los f\u00e1rmacos anti-inflamatorios no esteroideos y m\u00e1s recientemente los inhibidores selectivos de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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