{"id":77030,"date":"2005-04-11T00:00:00","date_gmt":"2005-04-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-in-vitro-del-efecto-de-la-oxotiazolidina-carboxilato-sobre-la-respuesta-radiobiologica-de-celulas-sanas-y-tumorales-de-cavidad-oral\/"},"modified":"2005-04-11T00:00:00","modified_gmt":"2005-04-11T00:00:00","slug":"estudio-in-vitro-del-efecto-de-la-oxotiazolidina-carboxilato-sobre-la-respuesta-radiobiologica-de-celulas-sanas-y-tumorales-de-cavidad-oral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia-clinica\/estudio-in-vitro-del-efecto-de-la-oxotiazolidina-carboxilato-sobre-la-respuesta-radiobiologica-de-celulas-sanas-y-tumorales-de-cavidad-oral\/","title":{"rendered":"Estudio in vitro del efecto de la oxotiazolidina-carboxilato sobre la respuesta radiobiol\u00f3gica de c\u00e9lulas sanas y tumorales de cavidad oral"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Javier Gonz\u00e1lez Velasco <\/strong><\/h2>\n<p>La radioterapia (rt) es uno de los tratamientos b\u00e1sicos de los tumores de cabeza y cuello. La mucositis y la xerostom\u00eda son los principales efectos t\u00f3xicos derivados de la aplicaci\u00f3n de la misma. La adici\u00f3n de quimioterapia concomitante, estrategia terap\u00e9utica habitual en estadios avanzados, as\u00ed como la aplicaci\u00f3n de fraccionamientos alterados, se corresponde con un incremento de los ya importantes efectos secundarios (mucositis) dando lugar a interrupciones del tratamiento, lo que reduce la eficacia del mismo y la calidad de vida del paciente. la utilizaci\u00f3n de agentes farmacol\u00f3gicos que, de forma simult\u00e1nea, incrementen el efecto de la radiaci\u00f3n sobre el tejido tumoral (radiosensibilizaci\u00f3n) y disminuyan la toxicidad sobre el tejido sano (radioprotecci\u00f3n), puede suponer un importante avance en rt. El presente estudio in vitro analiza el efecto del tratamiento con oxotiazolidina-carboxilato (otz, un modulador de los niveles intracelulares de glutati\u00f3n), y distintas dosis de irradiaci\u00f3n (125-1000 cgy), aplicados tanto de forma aislada como conjunta sobre l\u00edneas celulares de queratinocitos sanos de mucosa oral (qsmo) y c\u00e9lulas de carinoma escamoso de lengua (scc25). Se analiza igualmente la pauta m\u00e1s efectiva de aplicaci\u00f3n de otz en combinaci\u00f3n con rt, para finalmente analizar las diferencias derivadas de la aplicaci\u00f3n de diversas pautas de fraccionamiento radioter\u00e1pico: convencional (200 cgy\/d) e hiperfraccionado (125 cgy dos veces al d\u00eda), en ambos casos durante 5 d\u00edas consecutivos. las c\u00e9lulas se sometieron a rt con fotones de 6 mev (acelerador lineal, primus-siemens 18). El otz se administr\u00f3 a dosis de 0,5mm, 1 hora previa a cada fracci\u00f3n de rt, una vez haber sido determinada \u00e9sta como la pauta \u00f3ptima de administraci\u00f3n conjunta. Finalizado el tratamiento, se procedi\u00f3 al an\u00e1lisis de los \u00edndices de clonogenicidad (ic), obteniendo a partir de ellos los par\u00e1metros de fracci\u00f3n de supervivencia (fs), factor modificador de la radior<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio in vitro del efecto de la oxotiazolidina-carboxilato sobre la respuesta radiobiol\u00f3gica de c\u00e9lulas sanas y tumorales de cavidad oral<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio in vitro del efecto de la oxotiazolidina-carboxilato sobre la respuesta radiobiol\u00f3gica de c\u00e9lulas sanas y tumorales de cavidad oral <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Javier Gonz\u00e1lez Velasco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/11\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Bilbao Zulaica<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Gandarias y baj\u00f3n juna manuel <\/li>\n<li>Francisco L\u00f3pez lara (vocal)<\/li>\n<li> Rodr\u00edguez arrondo Jos\u00e9 Luis (vocal)<\/li>\n<li>lourdes De la pe\u00f1a fern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Javier Gonz\u00e1lez Velasco La radioterapia (rt) es uno de los tratamientos b\u00e1sicos de los tumores de cabeza [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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