{"id":77049,"date":"2005-07-11T00:00:00","date_gmt":"2005-07-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-multiparametrico-de-la-heterogeneidad-celullar-y-de-la-aneupluinizacion-en-meniongiomas-intracraneales-y-espinales\/"},"modified":"2005-07-11T00:00:00","modified_gmt":"2005-07-11T00:00:00","slug":"estudio-multiparametrico-de-la-heterogeneidad-celullar-y-de-la-aneupluinizacion-en-meniongiomas-intracraneales-y-espinales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia-clinica\/estudio-multiparametrico-de-la-heterogeneidad-celullar-y-de-la-aneupluinizacion-en-meniongiomas-intracraneales-y-espinales\/","title":{"rendered":"Estudio multiparametrico de la heterogeneidad celullar y de la aneupluinizacion en meniongiomas intracraneales y espinales"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 M\u00aa Sayagues Manzano <\/strong><\/h2>\n<p>Objetivo. Los objetivos del trabajo fueron: 1) determinar la incidencia de anomal\u00edas num\u00e9ricas de los cromosomas m\u00e1s frecuentemente alterados en meningiomas, investigando la presencia de distintos subclones de c\u00e9lulas neopl\u00e1sicas a nivel intratumoral, 2) analizar las implicaciones de las alteraciones gen\u00e9ticas detectadas en el comportamiento cl\u00ednico, biol\u00f3gico y evolutivo de los meningiomas e 3) investigar la posible influencia del micromedioambiente en el comportamiento del tumor, tomando como modelo la comparaci\u00f3n entre meningiomas intracraneales y espinales. m\u00e9todos. En conjunto analizamos un total de 155 pacientes con meningioma; en todos los casos investigamos la existencia de alteraciones num\u00e9ricas para los cromosomas 1, 9, 10, 11, 14, 15, 17, 18, 22, x e y empleando t\u00e9cnica  de hibridaci\u00f3n in situ fluorescente (fish), y su relaci\u00f3n con las caracter\u00edsticas cl\u00ednico-biol\u00f3gicas y evolutivas de la enfermedad. Paralelamente, en todas las muestras se realiz\u00f3 estudio del contenido de adn de las c\u00e9lulas tumorales mediante citometr\u00eda de flujo. Adem\u00e1s, en un subgrupo de 18 pacientes se analiz\u00f3 el patr\u00f3n de expresi\u00f3n g\u00e9nica empleando t\u00e9cnica de \u00abmicroarrays\u00bb de oligonucle\u00f3tidos. resultados y conclusiones. El 76% de los casos analizados mostraron alteraciones cromos\u00f3micas para las sondas utilizadas. Las p\u00e9rdidas cromos\u00f3micas m\u00e1s frecuentes fueron la monosom\u00eda \/deleci\u00f3n del cromosoma 22\/22q- en el conjunto de pacientes y la nulisom\u00eda y entre los varones (61% y 46% de los casos, respectivamente), mientras que las ganancias correspondieron a anomal\u00edas de los cromosomas 1 (27%), 9 (25%), 10 (23%), 11 (22%), 14 (33%), 15 (22%), 17(23%) y x (35% de las mujeres y 23% de los varones). Los estudios de fish mostraron que el 45% de los casos analizados presentaban un \u00fanico clon tumoral, correspondiendo todos estos casos a meningiomas histol\u00f3gicamente benignos; identific\u00e1ndose en los casos restantes (55%) dos \u00f3 m\u00e1s clones tumorales. El 64% de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio multiparametrico de la heterogeneidad celullar y de la aneupluinizacion en meniongiomas intracraneales y espinales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio multiparametrico de la heterogeneidad celullar y de la aneupluinizacion en meniongiomas intracraneales y espinales <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 M\u00aa Sayagues Manzano <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/11\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Alberto Orfao De Matos Correia E Vale<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alberto Gomez alonso <\/li>\n<li> De campos gutierrez Jos\u00e9 M\u00aa (vocal)<\/li>\n<li>Antonio Rey Juan (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Bello (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 M\u00aa Sayagues Manzano Objetivo. Los objetivos del trabajo fueron: 1) determinar la incidencia de anomal\u00edas num\u00e9ricas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[11771,347,9386],"tags":[9244,166065,166064,25781,166066,166063],"class_list":["post-77049","post","type-post","status-publish","format-standard","hentry","category-genetica-clinica","category-oncologia-clinica","category-salamanca","tag-alberto-gomez-alonso","tag-antonio-rey-juan","tag-de-campos-gutierrez-jose-ma","tag-jose-alberto-orfao-de-matos-correia-e-vale","tag-jose-maria-bello","tag-jose-ma-sayagues-manzano"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/77049","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=77049"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/77049\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=77049"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=77049"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=77049"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}