{"id":77145,"date":"2005-11-11T00:00:00","date_gmt":"2005-11-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estabilidad-plegamiento-y-asociacion-del-dominio-de-dimerizacion-de-la-proteina-de-la-capsida-del-virus-de-la-inmunodeficiencia-humana\/"},"modified":"2005-11-11T00:00:00","modified_gmt":"2005-11-11T00:00:00","slug":"estabilidad-plegamiento-y-asociacion-del-dominio-de-dimerizacion-de-la-proteina-de-la-capsida-del-virus-de-la-inmunodeficiencia-humana","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estabilidad-plegamiento-y-asociacion-del-dominio-de-dimerizacion-de-la-proteina-de-la-capsida-del-virus-de-la-inmunodeficiencia-humana\/","title":{"rendered":"Estabilidad, plegamiento y asociacion del dominio de dimerizacion de la proteina de la capsida del virus de la inmunodeficiencia humana"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Lidon Moya Mar\u00eda  Del Carmen <\/strong><\/h2>\n<p>El objetivo principal del presente trabajo ha sido la determinaci\u00f3n y caracterizaci\u00f3n de un compuesto con la capacidad de heterodimerizar con ca-c (dominio carboxilo terminal de la prote\u00edna de la c\u00e1psida del vih-1), e impedir de esta manera el ensamblaje natural de la c\u00e1psida, y en consecuencia, la infectividad del virus del sida. Para ello, el trabajo se divide en tres cap\u00edtulos.  en el primer cap\u00edtulo se ha llevado a cabo la caracterizaci\u00f3n termodin\u00e1mica de ca-c, mediante la utilizaci\u00f3n de diversas t\u00e9cnicas biof\u00edsicas: fluorescencia, dc, ftir, rmn, y cromatograf\u00eda de exclusi\u00f3n por tama\u00f1o molecular, a diferentes condiciones de ph y temperatura, con el fin de describir la estabilidad de las formas monom\u00e9rica y dim\u00e9rica de ca-c, y caracterizar cualquier posible intermediario que pueda aparecer en la reacci\u00f3n de plegamiento-asociaci\u00f3n de la prote\u00edna, as\u00ed como para comprender los factores energ\u00e9ticos que gobiernan la dimerizaci\u00f3n. Los resultados indican que el equilibrio de desnaturalizaci\u00f3n t\u00e9rmica de ca-c se compone de tres transiciones t\u00e9rmicas reversibles e independientes: (i) la primera transici\u00f3n (tm   307 k), que se observa por ftir y rmn, supone la disociaci\u00f3n del d\u00edmero de ca-c, dando lugar a un intermediario monom\u00e9rico plegado; (ii) la segunda transici\u00f3n (tm   325 k), observada por fluorescencia del ans, anisotrop\u00eda y dc en el ultravioleta cercano, implica el desplegamiento parcial del intermediario monom\u00e9rico plegado; y, (iii) la tercera transici\u00f3n (tm   332 k), que se observa por dc en el ultravioleta lejano, absorbancia, ftir y rmn, conlleva el desplegamiento global del intermediario monom\u00e9rico parcialmente plegado. Adem\u00e1s, tambi\u00e9n se han determinado los par\u00e1metros termodin\u00e1micos de la disociaci\u00f3n y desnaturalizaci\u00f3n de las formas dim\u00e9rica y monom\u00e9rica de ca-c a ph fisiol\u00f3gico. Se ha observado que ca-c, tanto en forma monom\u00e9rica como dim\u00e9rica, experimenta una transici\u00f3n conformacional<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estabilidad, plegamiento y asociacion del dominio de dimerizacion de la proteina de la capsida del virus de la inmunodeficiencia humana<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estabilidad, plegamiento y asociacion del dominio de dimerizacion de la proteina de la capsida del virus de la inmunodeficiencia humana <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Lidon Moya Mar\u00eda  Del Carmen <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/11\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Neira Faleiro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 manuel Gonzalez ros <\/li>\n<li>Javier Sancho sanz (vocal)<\/li>\n<li>mauricio Garcia mateu (vocal)<\/li>\n<li>Marta Bruix bayes (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lidon Moya Mar\u00eda Del Carmen El objetivo principal del presente trabajo ha sido la determinaci\u00f3n y caracterizaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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