{"id":77191,"date":"2018-03-09T23:22:40","date_gmt":"2018-03-09T23:22:40","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-farmacocinetico-de-una-nueva-fluoroquinolona-moxifloxacino-en-la-especie-caprina-disposicion-plasmatica-y-excreccion-en-leche\/"},"modified":"2018-03-09T23:22:40","modified_gmt":"2018-03-09T23:22:40","slug":"estudio-farmacocinetico-de-una-nueva-fluoroquinolona-moxifloxacino-en-la-especie-caprina-disposicion-plasmatica-y-excreccion-en-leche","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-farmacocinetico-de-una-nueva-fluoroquinolona-moxifloxacino-en-la-especie-caprina-disposicion-plasmatica-y-excreccion-en-leche\/","title":{"rendered":"Estudio farmacocin\u00e9tico de una nueva fluoroquinolona (moxifloxacino) en la especie caprina: disposici\u00f3n plasm\u00e1tica y excrecci\u00f3n en leche"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Lucia Villamayor Blanco <\/strong><\/h2>\n<p>Se ha estudiado el comportamiento cin\u00e9tico de una nueva fluoroquinolona, el moxifloxacino, en cabras en per\u00edodo de lactaci\u00f3n, tras su administraci\u00f3n por las v\u00edas intravenosa, intramuscular y subcut\u00e1nea a la dosis de 5 mg\/kg, con el fin de establecer sus par\u00e1metros farmacocin\u00e9ticos as\u00ed como su penetraci\u00f3n en leche.  la determinaci\u00f3n del moxifloxacino en plasma y en leche se realiz\u00f3 mediante hplc (siefert y cols., 1999). El ajuste a modelos farmacocin\u00e9ticos compartimentales se realiz\u00f3 mediante el programa multi (yamaoka y cols., 1981). El criterio utilizado para determinar cual era la ecuaci\u00f3n que mejor describ\u00eda los datos experimentales en cada caso, fue el criterio de informaci\u00f3n de akaike (aic) (yamaoka y cols., 1978).  tras la administraci\u00f3n intravenosa, el moxifloxacino se distribuy\u00f3 seg\u00fan un modelo bicompartimental abierto, y seg\u00fan un modelo monocompartimental en el caso de las v\u00edas intramuscular y subcut\u00e1nea.  el an\u00e1lisis de las concentraciones en leche para las tres v\u00edas de administraci\u00f3n se realiz\u00f3 utilizando el programa winnonline.  por lo que respecta al aclaramiento plasm\u00e1tico (cl), alcanz\u00f3 un valor \u00c2\u00b1 sd de 0.4241 \u00c2\u00b1 0.0952 tras la administraci\u00f3n intravenosa, y de 0.513 \u00c2\u00b1 0.114 y 0.4730 \u00c2\u00b1 0.1314 tras las administraciones im y sc, respectivamente. la vida media obtenida (t1\/2?Z) fue de 0.0983 h tras la administraci\u00f3n iv y de 1.263 y 3.3209 horas tras las administraciones im y sc.  la biodisponibilidad absoluta obtenida fue buena para las dos v\u00edas extravasculares, 88,0079 % para la v\u00eda im y 93.23 % para la v\u00eda sc.  la penetraci\u00f3n en leche de moxifloxacino alcanz\u00f3 unos elevados ratios, con unas relaciones aucleche\/aucplasma  mayor que 1.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio farmacocin\u00e9tico de una nueva fluoroquinolona (moxifloxacino) en la especie caprina: disposici\u00f3n plasm\u00e1tica y excrecci\u00f3n en leche<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio farmacocin\u00e9tico de una nueva fluoroquinolona (moxifloxacino) en la especie caprina: disposici\u00f3n plasm\u00e1tica y excrecci\u00f3n en leche <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Lucia Villamayor Blanco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/11\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Emilio Fern\u00e1ndez Var\u00f3n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Serrano caballero Juan  manuel <\/li>\n<li> Fern\u00e1ndez saavedra  Juan  ignacio (vocal)<\/li>\n<li>Alberto Espuny miro (vocal)<\/li>\n<li> Del rio Garc\u00eda Jes\u00fas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lucia Villamayor Blanco Se ha estudiado el comportamiento cin\u00e9tico de una nueva fluoroquinolona, el moxifloxacino, en cabras [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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