{"id":77291,"date":"2018-03-09T23:22:48","date_gmt":"2018-03-09T23:22:48","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-los-agentes-antioxidantes-en-modelos-experimentales-de-fibrosis-pulmonar\/"},"modified":"2018-03-09T23:22:48","modified_gmt":"2018-03-09T23:22:48","slug":"efecto-de-los-agentes-antioxidantes-en-modelos-experimentales-de-fibrosis-pulmonar","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-de-los-agentes-antioxidantes-en-modelos-experimentales-de-fibrosis-pulmonar\/","title":{"rendered":"Efecto de los agentes antioxidantes en modelos experimentales de fibrosis pulmonar"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Sonsoles Aragon Alvarez <\/strong><\/h2>\n<p>La fibrosis pulmonar es una patolog\u00eda inflamatoria cr\u00f3nica de inter\u00e9s cl\u00ednico y socioecon\u00f3mico, en las que el estres oxidativo juega un papel patog\u00e9nico susceptible de modulaci\u00f3n farmacol\u00f3gica mediante f\u00e1rmacos antioxidantes. la taurina ha demostrado un papel protector en la fibrosis pulmonar inducida por bleomicina en hamster por su papel antioxidante e inmunomodulador. se conoce la formaci\u00f3n de taurina a partir de n-acetil-l-ciste\u00edna (nac), dependiendo su transformaci\u00f3n de la actividad metab\u00f3lica de la cisteinasulfinatodecarboxilasa, siendo la rata una de las especies animales con elevada actividad enzimatica. en el ser humano la acivida de esta enzima es menor, sin embargo se ha demostrado categ\u00f3ricamente la s\u00edntesis de taurina en adultos, pero no est\u00e1 bien establecido si la administraci\u00f3n suplementaria de l-ciste\u00edna o dadores de l-ciste\u00edna podr\u00eda dar lugar a s\u00edntesis de taurina en el ser humano.  dise\u00f1amos un estudio experimental \u00abin vivo\u00bb donde nuestros objetivos fueron:  -estudiar los efectos de la taurina y l-nac en la fibrosis inducida por bleomicina en ratas  -correlacionar la activida de n-acetilciste\u00edna con los niveles de taurina  para ello establecimos cuatro gurpos aleatorios donde se administr\u00f3 tratamiento con nac vo o misma cantidad de suero salino en los grupos controles y la los 7 d\u00edas se provoc\u00f3 fibrosis pulmonar con la adminisraci\u00f3n de bleomicina intratraqueal o mismo volumen de suero salino para los grupos controles.  el estudio de la valoraci\u00f3n de la afectacion local provocada por la bleomicina lo realizamos mediante las determnaciones del peso pulmonar, hidroxiprolina en pulm\u00f3n (como marcador del dep\u00f3sito de col\u00e1geno), estudios histol\u00f3gicos con el grado histol\u00f3gico de las lesiones, recuento de c\u00e9lular y prote\u00ednas en el lavado broncolaveolar (lba) y estudios inmunohistoqu\u00edmicos. Para la valoraci\u00f3n de la afectaci\u00f3n sist\u00e9mica determinamos los cambios en el peso corporal, las pro<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de los agentes antioxidantes en modelos experimentales de fibrosis pulmonar<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de los agentes antioxidantes en modelos experimentales de fibrosis pulmonar <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Sonsoles Aragon Alvarez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/11\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Julio Cortijo Gimeno<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: esteban Morcillo sanchez <\/li>\n<li>Francisco Zaragoza garcia (vocal)<\/li>\n<li>Luis San roman (vocal)<\/li>\n<li>carmen Mar\u00eda Gonzalez garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Sonsoles Aragon Alvarez La fibrosis pulmonar es una patolog\u00eda inflamatoria cr\u00f3nica de inter\u00e9s cl\u00ednico y socioecon\u00f3mico, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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