{"id":77327,"date":"2018-03-09T23:22:48","date_gmt":"2018-03-09T23:22:48","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-apoptosis-in-vitro-en-leucemia-linfatica-cronica-b\/"},"modified":"2018-03-09T23:22:48","modified_gmt":"2018-03-09T23:22:48","slug":"caracterizacion-de-apoptosis-in-vitro-en-leucemia-linfatica-cronica-b","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-apoptosis-in-vitro-en-leucemia-linfatica-cronica-b\/","title":{"rendered":"Caracterizaci\u00f3n de apoptosis \u00abin vitro\u00bb en leucemia linf\u00e1tica cr\u00f3nica-b"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Betriz Alvarez Flores <\/strong><\/h2>\n<p>La leucemia linf\u00e1tica (llc-b) es el s\u00edndrome linfoproliferativo m\u00e1s frecuente del adulto y se caracteriza por la acumulaci\u00f3n progresiva de linfocitos b inmunol\u00f3gicamente incompetentes que generalmente sobreexpresan el ant\u00edgeno cd5. Esta acumulaci\u00f3n de linfocitos se debe principalmente a una inhibici\u00f3n de la muerte celular programada o apoptosis, permaneciendo las c\u00e9lulas en fase g0 del ciclo celular. La causa de dicha alteraci\u00f3n es desconocida. Cl\u00ednicamente los pacientes con llc-b presentan un comportamiento y una respuesta al tratamiento heterog\u00e9neo. Estudios sobre apoptosis aplicados a la llc-b, muestran un aumento en la expresi\u00f3n de la prote\u00edna antiapopt\u00f3tica -bcl-2, con aumento en el ratio bcl-2\/bax (prote\u00edna proapopt\u00f3tica) frente a los linfocitos b normales y aunque dicho ratio se ha correlacionado con el estadio cl\u00ednico de los pacientes existe en este momento controversia sobre su relaci\u00f3n con la respuesta cl\u00ednica al tratamiento. Es poco conocido el papel de otras prote\u00ednas implicadas en apoptosis en los pacientes con llc-b, pero miembros de la familia de bcl-2 como bax, bcl-x y mcl-1 podr\u00edan jugar un papel importante en este proceso. El an\u00e1lisis in vitro de apoptosis en llc-b, ha ofrecido igualmente resultados controvertidos sobre la correlaci\u00f3n entre apoptosis inducida in vitro por diferentes f\u00e1rmacos (fludarabina, 2-cda, clorambucil, flavopirinol, teofilina) y la respuesta cl\u00ednica al mismo.  igualmente los resultados ha sido contradictorios entre la relaci\u00f3n o no de quimiosensibilidad in vitro y los niveles de las diferentes prote\u00ednas implicadas en apoptosis. en el tratamiento de la llc-b, existen nuevas y distintas tendencias terap\u00e9uticas tras la aparici\u00f3n de un nuevo grupo de agentes citot\u00f3xicos, los an\u00e1logos de purinas, cuyos representantes m\u00e1s conocidos y empleados como eje del tratamiento de la llc-b son la fludarbina y la claridibina. actualmente, parece que el tratamiento de la llc-b se orienta hacia la utilizaci\u00f3<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n de apoptosis \u00abin vitro\u00bb en leucemia linf\u00e1tica cr\u00f3nica-b<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n de apoptosis \u00abin vitro\u00bb en leucemia linf\u00e1tica cr\u00f3nica-b <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Betriz Alvarez Flores <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/11\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Florinda Gilsanz Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  monica De la fuente del rey <\/li>\n<li>carmen Burgaleta alonso de ozalla (vocal)<\/li>\n<li>Juan  Antonio Vargas n\u00fa\u00f1ez (vocal)<\/li>\n<li> Cabrera mar\u00edn Jos\u00e9 Rafael (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Betriz Alvarez Flores La leucemia linf\u00e1tica (llc-b) es el s\u00edndrome linfoproliferativo m\u00e1s frecuente del adulto y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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