{"id":77354,"date":"2018-03-09T23:22:53","date_gmt":"2018-03-09T23:22:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-los-isoprostanos-en-la-reactividad-vascular-pulmonar-y-sistemica-durante-el-periodo-neonatal\/"},"modified":"2018-03-09T23:22:53","modified_gmt":"2018-03-09T23:22:53","slug":"efectos-de-los-isoprostanos-en-la-reactividad-vascular-pulmonar-y-sistemica-durante-el-periodo-neonatal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-de-los-isoprostanos-en-la-reactividad-vascular-pulmonar-y-sistemica-durante-el-periodo-neonatal\/","title":{"rendered":"Efectos de los isoprostanos en la reactividad vascular pulmonar y sist\u00e9mica durante el periodo neonatal"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gonz\u00e1lez Luis Gema Esther <\/strong><\/h2>\n<p>Introducci\u00f3n  los isoprostanos son compuestos similares a las prostaglandinas (pgs) que se producen mediante una peroxidaci\u00f3n no enzim\u00e1tica del \u00e1cido araquid\u00f3nico inducida por radicales libres (roberts &amp; morrow, 1997; morrow y cols., 1999). Debido a su semejanza estructural con las pgs, se postula  que no sean simples marcadores de la peroxidaci\u00f3n lip\u00eddica, sino que tambi\u00e9n posean actividad espec\u00edfica. Se ha investigado la funci\u00f3n biol\u00f3gica de los isoprostanos en animales adultos, en donde ejercen un efecto dual de predominio vasoconstrictor a nivel pulmonar y coronario. Sin embargo son muy pocos los referentes en este campo durante el per\u00edodo neonatal.  objetivos  1,- estudiar los efectos contr\u00e1ctiles y relajantes de diversos isoprostanos sobre vasos pulmonares y sist\u00e9micos de lechones reci\u00e9n nacidos (12-24h) comparado con lechones de 2 semanas (15-18 d\u00edas).  2,- dilucidar los mecanismos de transducci\u00f3n de las respuestas vasculares a los isoprostanos en estos tejidos.  animales experimentaci\u00f3n, material y m\u00e9todos  se estudi\u00f3 las respuestas contr\u00e1ctil y relajante de algunos isoprostanos (8-iso-pge1, 8-iso-pge2, 8-iso-pgf1beta, 8-iso-pgf2alfa, 8-iso-pgf2beta) y del mim\u00e9tico del tromboxano a2 -u46619- usando para ello el mi\u00f3grafo mediante la t\u00e9cnica del ba\u00f1o de \u00f3rgano. Se utilizaron anillos vasculares de la tercera rama de la arteria pulmonar (ap) y de la vena pulmonar (vp), del tronco principal de la arteria mesent\u00e9rica (am) y de la coronaria descente anterior izquierda (ac).  resultados  contracci\u00f3n: los isoprostanos producen una potente vasoconstricci\u00f3n dependiente de la concentraci\u00f3n en ap, vp y am (magnitudes 1,5-2 veces superiores a la respuesta de kci 62,5 mm), pero \u00e9sta resulta ser muy inferior a la vasoconstricci\u00f3n desarrollada por u46619. La ap del lech\u00f3n reci\u00e9n nacido resulta ser m\u00e1s sensibles a la acci\u00f3n de 8-iso-pge2, 8-iso-pgf1alta, 8-iso-pgf1beta y 8-iso-pgf2beta que la ap del<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de los isoprostanos en la reactividad vascular pulmonar y sist\u00e9mica durante el periodo neonatal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de los isoprostanos en la reactividad vascular pulmonar y sist\u00e9mica durante el periodo neonatal <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gonz\u00e1lez Luis Gema Esther <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/11\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Jimenez Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eduardo Dom\u00e9nech mart\u00ednez <\/li>\n<li>e. Blanco Carlos (vocal)<\/li>\n<li>alfredo Garllart catal\u00e1 (vocal)<\/li>\n<li>martin Iriondo sanz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gonz\u00e1lez Luis Gema Esther Introducci\u00f3n los isoprostanos son compuestos similares a las prostaglandinas (pgs) que se producen [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,155,9,957,161],"tags":[166616,126758,9917,166615,166617,1201],"class_list":["post-77354","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-ciencias-clinicas","category-ciencias-medicas","category-farmacologia","category-pediatria","tag-alfredo-garllart-catala","tag-e-blanco-carlos","tag-eduardo-domenech-Martinez","tag-gonzalez-luis-gema-esther","tag-martin-iriondo-sanz","tag-rafael-jimenez-gonzalez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/77354","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=77354"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/77354\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=77354"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=77354"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=77354"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}