{"id":77390,"date":"2018-03-09T23:22:53","date_gmt":"2018-03-09T23:22:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/hipertension-arterial-y-dano-organico-aproximacion-genomica-y-proteomica-a-la-hipertrofia-cardiaca-y-su-regresion\/"},"modified":"2018-03-09T23:22:53","modified_gmt":"2018-03-09T23:22:53","slug":"hipertension-arterial-y-dano-organico-aproximacion-genomica-y-proteomica-a-la-hipertrofia-cardiaca-y-su-regresion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/hipertension-arterial-y-dano-organico-aproximacion-genomica-y-proteomica-a-la-hipertrofia-cardiaca-y-su-regresion\/","title":{"rendered":"Hipertension arterial y da\u00f1o organico. aproximacion genomica y proteomica a la hipertrofia cardiaca y su regresion"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Julio Gallego Delgado <\/strong><\/h2>\n<p>La hipertensi\u00f3n arterial es la enfermedad cr\u00f3nica m\u00e1s frecuente en el mundo desarrollado y uno de los problemas de salud p\u00fablica m\u00e1s importante de los pa\u00edses occidentales. La hipertensi\u00f3n es la causa m\u00e1s importante de la hipertrofia ventricular izquierda (hvi), un fuerte indicador de enfermedad cardiovascular y el predictor m\u00e1s fiable de fallo cardiaco en el mundo occidental. Existen disponibles un amplio rango de f\u00e1rmacos para el tratamiento de la hipertensi\u00f3n arterial, sin embargo, a pesar de su efectividad reduciendo los niveles de presi\u00f3n arterial, no hay ninguno que ofrezca un perfil organo-protector completo. En esta tesis, utilizando un modelo experimental de hipertensi\u00f3n cr\u00f3nica y distintos regimenes antihipertensivos, hemos constatado efectos organo protectores distintos asociados al control de la presi\u00f3n arterial y\/o al tipo de f\u00e1rmaco utilizado. Por otra parte, utilizando una doble aproximaci\u00f3n gen\u00f3mica y prote\u00f3mica, hemos comprobado que la hvi mediada por hipertensi\u00f3n presenta graves alteraciones a nivel molecular en la fisiolog\u00eda del cardiomiocito. Adem\u00e1s, hemos visto que la regresi\u00f3n de la hvi no est\u00e1 asociada a una completa recuperaci\u00f3n de su transcriptoma ni de su proteoma. por tanto, el coraz\u00f3n con hvi regresada conserva todav\u00eda caracter\u00edsticas moleculares propias del coraz\u00f3n hipertr\u00f3fico. Estos genes y prote\u00ednas que permanecen alterados juegan papeles claves en v\u00edas energ\u00e9ticas, en la defensa al estr\u00e9s y en la regulaci\u00f3n de la hipertrofia. Por tanto, estos datos pueden ofrecer potenciales nuevas v\u00edas implicadas en la enfermedad cardiaca mediada por hipertensi\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Hipertension arterial y da\u00f1o organico. aproximacion genomica y proteomica a la hipertrofia cardiaca y su regresion<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Hipertension arterial y da\u00f1o organico. aproximacion genomica y proteomica a la hipertrofia cardiaca y su regresion <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Julio Gallego Delgado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/11\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Egido De Los Rios<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Miguel Blanco colio <\/li>\n<li> Martinez selles d oliviera soares Manuel (vocal)<\/li>\n<li>Fernando Vivanco mart\u00ednez (vocal)<\/li>\n<li>Jes\u00fas m. San roman montero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Julio Gallego Delgado La hipertensi\u00f3n arterial es la enfermedad cr\u00f3nica m\u00e1s frecuente en el mundo desarrollado y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,2445,957,52,156,1601,1323],"tags":[6523,5119,59210,139080,47106,166686],"class_list":["post-77390","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-evaluacion-de-farmacos","category-farmacologia","category-histopatologia","category-patologia","category-patologia-cardiovascular","category-patologia-experimental","tag-fernando-vivanco-Martinez","tag-jesus-egido-de-los-rios","tag-jesus-m-san-roman-montero","tag-julio-gallego-delgado","tag-luis-miguel-blanco-colio","tag-Martinez-selles-d-oliviera-soares-manuel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/77390","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=77390"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/77390\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=77390"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=77390"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=77390"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}