{"id":77393,"date":"2018-03-09T23:22:53","date_gmt":"2018-03-09T23:22:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-y-aplicacion-de-metodos-moleculares-para-la-deteccion-de-enfermedad-microdiseminada-y-micrometastasis\/"},"modified":"2018-03-09T23:22:53","modified_gmt":"2018-03-09T23:22:53","slug":"desarrollo-y-aplicacion-de-metodos-moleculares-para-la-deteccion-de-enfermedad-microdiseminada-y-micrometastasis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/analisis-de-farmacos\/desarrollo-y-aplicacion-de-metodos-moleculares-para-la-deteccion-de-enfermedad-microdiseminada-y-micrometastasis\/","title":{"rendered":"Desarrollo y aplicaci\u00f3n de m\u00e9todos moleculares para la detecci\u00f3n de enfermedad microdiseminada y micromet\u00e1stasis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gonzalo G\u00f3mez L\u00f3pez <\/strong><\/h2>\n<p>La supervivencia global de los pacientes con c\u00e1ncer no ha variado notablemente en los \u00faltimos a\u00f1os. La principal raz\u00f3n de este fracaso es la expresi\u00f3n temprana de un fenotipo invasivo en los tumores primarios. La valoraci\u00f3n de m\u00faltiples marcadores asociados al tumor es fundamental para determinar la presencia de c\u00e9lulas microdiseminadas y, potencialmente, metast\u00e1sicas. Sin embargo la escasez demarcadores de microdiseminaci\u00f3n tumoral temprana contin\u00faa siendo una limitaci\u00f3n a d\u00eda de hoy.  en este trabajo se aplican t\u00e9cnicas de biolog\u00eda molecular para el estudio de la diseminaci\u00f3n tumoral y la micromet\u00e1stasis en muestras cl\u00ednicas. Para ello se lleva a cabo un estudio por rt-pcr del marcador tirosinasa (tyr) en tejido ganglionar, sangre y plasma de pacientes con melanoma maligno. Adem\u00e1s, se aplican t\u00e9cnicas de an\u00e1lisis m\u00faltiple de expresi\u00f3n g\u00e9nica diferencial sobre un modelo de l\u00edneas celulares humanas y metast\u00e1sicas, con objeto de proponer nuevos genes candidatos a marcadores de met\u00e1stasis. Finalmente, se estudian los patrones de expresi\u00f3n g\u00e9nica de la l\u00ednea celular humanas y metast\u00e1sica pcr3, en presencia de zoledronato con el objetivo de proponer dianas terap\u00e9uticas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo y aplicaci\u00f3n de m\u00e9todos moleculares para la detecci\u00f3n de enfermedad microdiseminada y micromet\u00e1stasis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo y aplicaci\u00f3n de m\u00e9todos moleculares para la detecci\u00f3n de enfermedad microdiseminada y micromet\u00e1stasis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gonzalo G\u00f3mez L\u00f3pez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/11\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Enrique Caso Pel\u00e1ez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: trinidad Caldes llopis <\/li>\n<li>belen Penal fuentes (vocal)<\/li>\n<li>lucia Chac\u00f3n vargas (vocal)<\/li>\n<li>Emilio Vicente l\u00f3pez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gonzalo G\u00f3mez L\u00f3pez La supervivencia global de los pacientes con c\u00e1ncer no ha variado notablemente en los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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