{"id":77455,"date":"2018-03-09T23:23:01","date_gmt":"2018-03-09T23:23:01","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/funcion-de-las-metalotioneinas-en-la-patogenia-de-la-encefalomielits-autoinmune-experimental-y-de-la-esclerosis-multiple-implicaciones-terapeuticas\/"},"modified":"2018-03-09T23:23:01","modified_gmt":"2018-03-09T23:23:01","slug":"funcion-de-las-metalotioneinas-en-la-patogenia-de-la-encefalomielits-autoinmune-experimental-y-de-la-esclerosis-multiple-implicaciones-terapeuticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/funcion-de-las-metalotioneinas-en-la-patogenia-de-la-encefalomielits-autoinmune-experimental-y-de-la-esclerosis-multiple-implicaciones-terapeuticas\/","title":{"rendered":"Funci\u00f3n de las metalotioneinas en la patogenia de la encefalomielits autoinmune experimental y de la esclerosis m\u00faltiple. implicaciones terap\u00e9uticas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Espejo Ruiz <\/strong><\/h2>\n<p>La esclerosis m\u00faltiple (em) es una enfermedad cr\u00f3nica, inflamatoria y desmielinizante del sistema nervioso central (snc) siendo la principal causa de discapacidad en adultos j\u00f3venes despu\u00e9s d elos traumatismos. Su preValencia en nuestra \u00e1rea geogr\u00e1fica es aproximadamente 60-70 pacientes cada 1000.000 habitantes. la causa de la enfermedad es a\u00fan deconocida y se han implicado tanto factores gen\u00e9ticos como ambientales. Se considera que es una enfermedad mediada por el sistema inmunitario, donde linfocitos t activados en perifria son capaces de reconocer ant\u00edgenos dela mielina en el snc y desencadenar el proceso autoinmune que culminr\u00e1 conla destrucci\u00f3n de la mielina, de forma que la conducci\u00f3n nerviosa puede afectarse y aparecer los signos y s\u00edntomas caracter\u00edsticos de la enfermedad.  existen evidencias de que el estr\u00e9s oxidativo tinee una funci\u00f3n importante en el desarrollo de la lesi\u00f3n en el snc. En este sentido, se ha observado que el estr\u00e9s oxidativo puede causar da\u00f1o axonal y que el da\u00f1o axonal contribuye a la discapacidad neurol\u00f3gica que se produce en la em.  en el snc de pacientes con em se ha observado expresi\u00f3n de marcadores de estr\u00e9s oxidativo, correlacion\u00e1ndose con el proceso inflamatorio y desmielinizante que se produce en la enfermedad. Por otro lado, los pacientes con em tienen disminuidos, respecto a controles sanos, los niveles s\u00e9ricos de diferentes antioxidantes naturales como enzimas, vitaminas, ubicuinona, etc. Las metalotine\u00ednas (mt) son unas prote\u00ednas para las que se han descrito propiedades antioxidantes, anti-inflamatorias y neuroprotectoras en situaciones donde se produce estr\u00e9s oxidativo. En este contexto, nos planteamos estudiar la funci\u00f3n de las mt en la patogen\u00eda de la esclerosis m\u00faltiple y sus posibles implicaciones terap\u00e9uticas, para ello utilizamos el modelo animal de esclerosis m\u00faltiple, la encefalomielitis autoinmune experimental (eae).  observamos que la expresi\u00f3n de mt<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Funci\u00f3n de las metalotioneinas en la patogenia de la encefalomielits autoinmune experimental y de la esclerosis m\u00faltiple. implicaciones terap\u00e9uticas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Funci\u00f3n de las metalotioneinas en la patogenia de la encefalomielits autoinmune experimental y de la esclerosis m\u00faltiple. implicaciones terap\u00e9uticas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Espejo Ruiz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/11\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Xavier Montalban<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: miquel Vilardel <\/li>\n<li>Juan Hidalgo (vocal)<\/li>\n<li>roland Martin (vocal)<\/li>\n<li>joan Verdaguer (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Espejo Ruiz La esclerosis m\u00faltiple (em) es una enfermedad cr\u00f3nica, inflamatoria y desmielinizante del sistema nervioso [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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