{"id":77476,"date":"2018-03-09T23:23:01","date_gmt":"2018-03-09T23:23:01","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interferencia-entre-va%c2%adas-de-senalizacion-que-median-supervivencia-y-proliferacion-en-queratinocitos-implicaciones-en-carcinogenesis-epidermica\/"},"modified":"2018-03-09T23:23:01","modified_gmt":"2018-03-09T23:23:01","slug":"interferencia-entre-va%c2%adas-de-senalizacion-que-median-supervivencia-y-proliferacion-en-queratinocitos-implicaciones-en-carcinogenesis-epidermica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/interferencia-entre-va%c2%adas-de-senalizacion-que-median-supervivencia-y-proliferacion-en-queratinocitos-implicaciones-en-carcinogenesis-epidermica\/","title":{"rendered":"Interferencia entre v\u00edas de se\u00f1alizaci\u00f3n que median supervivencia y proliferaci\u00f3n en queratinocitos: implicaciones en carcinog\u00e9nesis epid\u00e9rmica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Hugo Leis Martinez <\/strong><\/h2>\n<p>Nf-kappab, p13k1akt y gr son mol\u00e9culas esenciales que participan, de una manera conjunta y coordinada, en el control de diversos aspectos de la homeostasis de los queratinocitos, incluyendo la resistencia a la apoptosis, la proliferaci\u00f3n y la diferenciaci\u00f3n epid\u00e9rmica, asi como el proceso inflamatorio cut\u00e1neo. El complejo ikk es un punto central en la regulaci\u00f3n de la actividad nf-kb y numerosas se\u00f1ales convergen en \u00e9l. La subunidad reguladora ikkgamma es esencial para la funci\u00f3n del complejo ikk y su falta de funci\u00f3n total o parcial se correlaciona con diversas patolog\u00edas humanas que se caracterizan por defectos primarios en uno o m\u00e1s epitelios. En este trabajo hemos abordado el estudio funcional de ikkg en queratinocitos en cultivo y en piel de rat\u00f3n in vivo, mediante el uso del mutante de delecci\u00f3n ikkg-dn97, que act\u00faa como un dominante negativo de funci\u00f3n nf-kb. Ikkg-dn97 provoca el desacoplamiento de los complejos, dando como resultado una inhibici\u00f3n parcial y dependiente de dosis de la actividad nf-kb inducible. Adem\u00e1s produce alteraciones morfol\u00f3gicas y un aumento de la apoptosis de los queratinocitos sin estimular, bloqueando la degradaci\u00f3n de ikappabalpha y la localizaci\u00f3n nuclear de p65, aumentando los niveles de pten y reduciendo la fosforilaci\u00f3n de akt. Hemos generado ratones transg\u00e9nicos que expresan ikkg-dn97 en los queratinocitos basa les de la epidermis y otros epitelios estratificados (k5-ikkg-dn97), los cuales presentan alteraciones en la morfog\u00e9nesis folicular y la respuesta inflamatoria cut\u00e1nea. Mediante aproximaciones de tumorig\u00e9nesis in vivo, hemos demostrado que akt contribuye a la progresi\u00f3n tumoral de los queratinocitos a trav\u00e9s de la inhibici\u00f3n parcial de gsk3beta, permitiendo la localizaci\u00f3n nuclear de cycd1 mediante diversos mecanismos que aumentan la expresi\u00f3n y estabilidad de la ciclina.  asimismo, hemos demostrado que parte de los efectos antitumorales de los gcs durante la carc<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Interferencia entre v\u00edas de se\u00f1alizaci\u00f3n que median supervivencia y proliferaci\u00f3n en queratinocitos: implicaciones en carcinog\u00e9nesis epid\u00e9rmica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Interferencia entre v\u00edas de se\u00f1alizaci\u00f3n que median supervivencia y proliferaci\u00f3n en queratinocitos: implicaciones en carcinog\u00e9nesis epid\u00e9rmica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Hugo Leis Martinez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/11\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Bravo Del Moral Ana M.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: victor manuel Arce vazquez <\/li>\n<li>Ana Aranda iriarte (vocal)<\/li>\n<li> Ramos mart\u00ednez ju\u00e1n ignacio (vocal)<\/li>\n<li>Rafael Pulido murillo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Hugo Leis Martinez Nf-kappab, p13k1akt y gr son mol\u00e9culas esenciales que participan, de una manera conjunta y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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