{"id":77515,"date":"2005-01-12T00:00:00","date_gmt":"2005-01-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/productos-naturales-marinos-del-parque-nacional-coiba-panama-metabolitos-con-actividad-antiprotozoaria\/"},"modified":"2005-01-12T00:00:00","modified_gmt":"2005-01-12T00:00:00","slug":"productos-naturales-marinos-del-parque-nacional-coiba-panama-metabolitos-con-actividad-antiprotozoaria","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/productos-naturales-marinos-del-parque-nacional-coiba-panama-metabolitos-con-actividad-antiprotozoaria\/","title":{"rendered":"Productos naturales marinos del parque nacional coiba panam\u00e1: metabolitos con actividad antiprotozoaria."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marcelino Guti\u00e9rrez Guevara <\/strong><\/h2>\n<p>En esta tesis se describe el aislamiento, determinaci\u00f3n estructral y actividad farmacol\u00f3gica de una serie de productos naturales aislados de las esponjas aplysina chiriquiensis y aplysina gerardogreeni y de los octocorales leptogorgia alba, leptogorgia rigida y muricea astera, recolectados en el parqe nacional coiba, localizado en el pac\u00edfico de panam\u00e1.  la determinaci\u00f3n estructural de los metabolitos aislados y la configuraci\u00f3n absoluta de los compuestos nuevos, se llev\u00f3 a cabo mediante el uso exhaustivo de resonancia magn\u00e9tica nuclear, espectrometr\u00eda de masas, difracci\u00f3n de rayos-x y dicr\u00edsmo circular. Se ha sintetizado y eval\u00faado la actividad antiprotozoaria de una serie de an\u00e1logos de los productos naturales aislados. .  los extractos crudos de las esponjas aplysina chiriquiensis y a. Gerardogreeni mostraron un potente efecto inhibitorio sobre el crecimiento de la bacteria marina pat\u00f3gena vibrio anguillarum y actividad antiprotozoaria contra plasmodium falciparum resistente a la cloroquina. El fraccionamiento de a. Chiriquiensis dirigido por ensayos biol\u00f3gicos llev\u00f3 al aislamiento de cinco dibromotirosinas. comparaciones por hplc indicaron que ambas esponjas poseen una composici\u00f3n qu\u00edmica similar, aunque con variaciones en la proporci\u00f3n de los metabolitos. el aeroplysinin-1 se encontr\u00f3 como el principio activo responsable de la potente actividad antibacteriana obsenada en los extractos crudos de ambas esponjas, as\u00ed como de la actividad antiprotozoaria contra plasmodium falciparum y tripanosoma cruzi.  de las gorgonias l. Alba y l. Rigida se aislaron siete diterpenos. Se describe por primera vez la estructura de la leptolida. Se ha asignado la configuraci\u00f3n absoluta de los siete diterpenos por medio de difracci\u00f3n de los rayos-x, dicro\u00edsmo circular, y la correlaci\u00f3n de los resultados aqu\u00ed obtenidos con transformaciones qu\u00edmicas descritas en la bibliograf\u00eda. Se describe por vez primera la actividad antimal\u00e1<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Productos naturales marinos del parque nacional coiba panam\u00e1: metabolitos con actividad antiprotozoaria.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Productos naturales marinos del parque nacional coiba panam\u00e1: metabolitos con actividad antiprotozoaria. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marcelino Guti\u00e9rrez Guevara <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/12\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ricardo Riguera Vega<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enrique Ravi\u00f1a rubira <\/li>\n<li>librada Mar\u00eda Ca\u00f1edo hern\u00e1ndez (vocal)<\/li>\n<li>Jaime Rodr\u00edguez gonz\u00e1lez (vocal)<\/li>\n<li>concepci\u00f3n \u00e1vila escart\u00edn (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marcelino Guti\u00e9rrez Guevara En esta tesis se describe el aislamiento, determinaci\u00f3n estructral y actividad farmacol\u00f3gica de una [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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