{"id":77516,"date":"2005-01-12T00:00:00","date_gmt":"2005-01-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/multi-state-mdels-formbiomedical-research-new-contributions-in-statistical-lmodelling-sofware-development-and-applications\/"},"modified":"2005-01-12T00:00:00","modified_gmt":"2005-01-12T00:00:00","slug":"multi-state-mdels-formbiomedical-research-new-contributions-in-statistical-lmodelling-sofware-development-and-applications","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/matematicas\/multi-state-mdels-formbiomedical-research-new-contributions-in-statistical-lmodelling-sofware-development-and-applications\/","title":{"rendered":"Multi-state mdels formbiomedical research. new contributions in statistical lmodelling, sofware development, and applications."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Meira Machado Lu\u00eds Filipe <\/strong><\/h2>\n<p>La progresi\u00f3n de una cierta enfermedad puede describirse a trav\u00e9s de los modelos multi-estado. Estos modelos pueden considerarse como una generalizaci\u00f3n del proceso de supervivencia donde varios eventos (intermedios) ocurren consecutivamente en el tiempo. En este contexto, algunos problemas de inter\u00e9s son: la estimaci\u00f3n de tasas de progresi6n, la evaluacl6n de los efectos de factores de riesgo individuales, o la estimaci\u00f3n de la tasa de supervivencia. La influencia de estos eventos intermedios en la supervivencia es analizada habitualmente a trav\u00e9s del modelo de regresi\u00f3n de cox.  esta tesis contiene una revisi\u00f3n exhaustiva de los modelos multi-estado m\u00e1s habituales para estudiar la progresi\u00f3n de la enfermedad. Se discuten las diferencias entre estos modelos y el modelo de regresi6n de cox, enfatizando las posibles ventajas y desventajas de cada m\u00e9todo. Los m\u00e9todos revisados se ilustran con los datos de transplante de coraz\u00f3n de stanford, proporcionando un gula sobre el uso de estas metodologlas para el estudio de la evoluci\u00f3n de la enfermedad. Una atenci6n especial debe prestarse cuando se est\u00e1 interesado en evaluar el efecto de una covariable. El modelo de cox proporciona-estimaciones constantes del efecto de la covariable a lo largo del periodo de estudio.-Para-evitar este problema se utilizan-m\u00e9todos ae  suavizaci\u00f3n spline (p-splines). Adem\u00e1s, son introducidos estos m\u00e9todos spline en modelos multi-estado para averiguar los posibles efectos no-lineales de las covariables en las intensidades de transici\u00f3n.  el uso de estos m\u00e9todos en modelos mutti-estado es novedoso. Para ilustrar los posibles beneficios del uso de los modelos multi-estado, se realizaron varios estudios de simulaci\u00f3n. A trav\u00e9s de estos estudios, se explica por qu\u00e9 el modelo de cox puede no  ser apropiado (con interpretaci\u00f3n dificil) cuando se utiliza en presencia de covariables dependientes del tiempo.  tradicionalmente, los m\u00e9todos estadi<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Multi-state mdels formbiomedical research. new contributions in statistical lmodelling, sofware development, and applications.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Multi-state mdels formbiomedical research. new contributions in statistical lmodelling, sofware development, and applications. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Meira Machado Lu\u00eds Filipe <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/12\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmen Cadarso Su\u00e1rez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: wenceslao Gonz\u00e1lez manteiga <\/li>\n<li>andersen Per kragh (vocal)<\/li>\n<li>winfried Stute (vocal)<\/li>\n<li>ingrid Van keilegom (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Meira Machado Lu\u00eds Filipe La progresi\u00f3n de una cierta enfermedad puede describirse a trav\u00e9s de los modelos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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