{"id":77551,"date":"2005-02-12T00:00:00","date_gmt":"2005-02-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modelo-cla%c2%adnico-predictivo-para-la-deteccion-de-pacientes-con-alto-riesgo-de-reacciones-sistemicas-por-inmunoterapia-alergeno-especa%c2%adfica\/"},"modified":"2005-02-12T00:00:00","modified_gmt":"2005-02-12T00:00:00","slug":"modelo-cla%c2%adnico-predictivo-para-la-deteccion-de-pacientes-con-alto-riesgo-de-reacciones-sistemicas-por-inmunoterapia-alergeno-especa%c2%adfica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/alergias\/modelo-cla%c2%adnico-predictivo-para-la-deteccion-de-pacientes-con-alto-riesgo-de-reacciones-sistemicas-por-inmunoterapia-alergeno-especa%c2%adfica\/","title":{"rendered":"Modelo cl\u00ednico predictivo para la detecci\u00f3n de pacientes con alto riesgo de reacciones sist\u00e9micas por inmunoterapia al\u00e9rgeno-espec\u00edfica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Luis Justicia Ruano <\/strong><\/h2>\n<p>Objetivo     determinar qu\u00e9 factores se asocian a un mayor riesgo de sufrir reacciones sist\u00e9micas (rs) por inmunoterapia al\u00e9rgeno-espec\u00edfica (ite), y construir con ellos un modelo de predicci\u00f3n cl\u00ednica, que permita la estratificaci\u00f3n de pacientes seg\u00fan su riesgo.  pacientes y m\u00e9todos     estudio observacional, prospectivo, en el que, durante 7 a\u00f1os (1996 a 2002) se registraron las rs de pacientes que recib\u00edan ite agrupada para el tratamiento de su alergia respiratoria, causada por polen de olivo o gram\u00edneas. mediante regresi\u00f3n log\u00edstica simple, se determin\u00f3 la asociaci\u00f3n entre rs y variables relacionadas con el paciente (sexo, edad, enfermedad, gravedad, a\u00f1os de evoluci\u00f3n, ite previa, s\u00edntomas extraprimaverales, prick-test, sensibilizaci\u00f3n a otros al\u00e9rgenos, ige total, ige espec\u00edfica), con al pauta, con el extracto composici\u00f3n, lote) y con el entorno (a\u00f1o de administraci\u00f3n, trimestre, comarca y h\u00e1bitat). Como variables candidatas se seleccionaron aqu\u00e9llas que alcanzaron un nivel de significaci\u00f3n alfa menor 0.30. El modelo definitivo se construy\u00f3 mediante regresi\u00f3n log\u00edstica m\u00faltiple, permaneciendo las variables con nivel de significaci\u00f3n menor 0.05.   resultados     de los 611 pacientes seleccionados, 65 (10.6%) tuvieron rs. de todas las variables analizadas, s\u00f3lo 7 permanecieron en el modelo final: edad mayor 14 a\u00f1os (or = 0.3), sensibilizaci\u00f3n a quenopodi\u00e1ceas (or =3.0), ige-olivo elevada (or )= 4.1), ige-gram\u00edneas elevada (or = 2.3), composici\u00f3n ilivo 100% (or = 2.6) y pauta (or = 1.6 a 7.1, seg\u00fan la pauta).  conclusiones     con variables cl\u00edncias f\u00e1ciles de determinar, se ha desarrollado un modelo predictivo que permite calcular el riesgo a priori de reacciones sist\u00e9micas por inmunoterpaia (desde 0.3% hasta 84.3%). La detecci\u00f3n de aquellos pacientes con riesgo m\u00e1s elevado permite adoptar medidas de intervenci\u00f3n para prevenir las reacciones sist\u00e9micas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modelo cl\u00ednico predictivo para la detecci\u00f3n de pacientes con alto riesgo de reacciones sist\u00e9micas por inmunoterapia al\u00e9rgeno-espec\u00edfica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modelo cl\u00ednico predictivo para la detecci\u00f3n de pacientes con alto riesgo de reacciones sist\u00e9micas por inmunoterapia al\u00e9rgeno-espec\u00edfica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Luis Justicia Ruano <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/12\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Blas Gil Extremera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Campos mu\u00f1oz <\/li>\n<li>Francisco Guerras pasadas (vocal)<\/li>\n<li>Emilio S\u00e1nchez-cantalejo rodr\u00edguez (vocal)<\/li>\n<li>carmen Moreno aguilar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Luis Justicia Ruano Objetivo determinar qu\u00e9 factores se asocian a un mayor riesgo de sufrir reacciones 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