{"id":77562,"date":"2005-02-12T00:00:00","date_gmt":"2005-02-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-estructural-y-funcional-del-regulador-transcripcional-sigma-54-dependiente-tour\/"},"modified":"2005-02-12T00:00:00","modified_gmt":"2005-02-12T00:00:00","slug":"estudio-estructural-y-funcional-del-regulador-transcripcional-sigma-54-dependiente-tour","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-estructural-y-funcional-del-regulador-transcripcional-sigma-54-dependiente-tour\/","title":{"rendered":"Estudio estructural y funcional del regulador transcripcional sigma-54 dependiente tour"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Faustino Vidal Aroca <\/strong><\/h2>\n<p>El activador transcripcional sigma54-dependiente tour regula la expresi\u00f3n del oper\u00f3n tou de pseudomonas stutzeri ox1 en respuesta a metil-fenoles. Tour pertenece a la familia de reguladores ntrc. Estos reguladores sigma54-dependientes presentan una estructura organizada en varios dominios:     1,- un dominio central c, altamente conservado, que lleva a cabo las funciones fundamentales para la activaci\u00f3n de la transcripci\u00f3n, tales como la uni\u00f3n e hidr\u00f3lisis del atp, la multimerizaci\u00f3n y la interacci\u00f3n con la sigma54-arnpolimerasa.     2,- un dominio a n-terminal, caracter\u00edstico de cada subgrupo de la familia que est\u00e1 involucrado en la respuesta a se\u00f1ales medioambientales (en el caso de tour, respuesta a metil-fenoles).     3,- un dominio d c-terminal responsable de la uni\u00f3n al adn promotor.     4,- un dominio-b que aparentemente juega un papel de regulaci\u00f3n como conector estructural entre los dominios a y c.      la arquitectura molecular de tour y la respuesta conformacional debida a la uni\u00f3n del metil-fenol est\u00e1n todav\u00eda por caracterizar. El objetivo de esta tesis ha sido el de obtener una huella estructural de tour mediante dicro\u00edsmo circular, espectroscop\u00eda de fluorescencia y modernizaci\u00f3n de la estructura tridimensional. Adem\u00e1s, para analizar los distintos sub-dominios funcionales, fue generada una colecci\u00f3n de variantes de tour mediante mutag\u00e9nesis insercional de pentap\u00e9ptidos a lo largo de toda la mol\u00e9cula, cuya capacidad para activar la transcripci\u00f3n fue evaluada.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio estructural y funcional del regulador transcripcional sigma-54 dependiente tour<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio estructural y funcional del regulador transcripcional sigma-54 dependiente tour <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Faustino Vidal Aroca <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/12\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Giovanni Bertoni<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: julian Perera gonzalez <\/li>\n<li>eudardo Diaz fernandez (vocal)<\/li>\n<li>victor De lorenzo prieto (vocal)<\/li>\n<li>ildefonso Cases diaz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Faustino Vidal Aroca El activador transcripcional sigma54-dependiente tour regula la expresi\u00f3n del oper\u00f3n tou de pseudomonas stutzeri [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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