{"id":77580,"date":"2005-02-12T00:00:00","date_gmt":"2005-02-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-inducidas-por-dieta-deficiente-en-vitamina-a-sobre-membrana-basal-de-rinon-de-rata\/"},"modified":"2005-02-12T00:00:00","modified_gmt":"2005-02-12T00:00:00","slug":"alteraciones-inducidas-por-dieta-deficiente-en-vitamina-a-sobre-membrana-basal-de-rinon-de-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/alteraciones-inducidas-por-dieta-deficiente-en-vitamina-a-sobre-membrana-basal-de-rinon-de-rata\/","title":{"rendered":"Alteraciones inducidas por dieta deficiente en vitamina a sobre membrana basal de ri\u00f1on de rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Del Pilar Marin Muela <\/strong><\/h2>\n<p>La deficiencia en vitamina a es un grave y com\u00fan trastorno nutricional, que afecta cl\u00ednicamente a m\u00e1s de 5 millones de personas al a\u00f1o, fundamentalmente ni\u00f1os. Es causa habitual de muerte infantil en pa\u00edses en v\u00edas de desarrollo donde se estima que m\u00e1s de un mill\u00f3n de ni\u00f1os mueren anualmente por causas asociadas a esta deficiencia. No solamente lo pa\u00edses en v\u00edas de desarrollo son diana de esta deficiencia, sino que en los pa\u00edses desarrollados se estima que m\u00e1s de un 20% de la poblaci\u00f3n no alcanza los niveles de ingesta recomendados, presentando niveles plasm\u00e1ticos y hep\u00e1ticos de esta vitamina inferiores a lo normal. Esta situaci\u00f3n puede agravarse por la tendencia a reducir la ingesta de grasa en la dieta, as\u00ed como con los reg\u00edmenes incontrolados de p\u00e9rdida de peso.  los retinoides pueden regular la expresi\u00f3n de distintas prote\u00ednas propias de la matriz extracelular. Los cambios en dichas prote\u00ednas pueden alterar la composici\u00f3n y la funci\u00f3n de las membranas basales, que son formas altamente especializadas de  matriz extracelular. En este trabajo se estudian los efectos que la deficiencia en vitamina a, originada por una privaci\u00f3n de dicha vitamina en la dieta, causa sobre la membrana basal renal  durante el periodo de crecimiento. Para llevarlo a cabo utilizamos ratas macho de la raza wistar, que fueron privadas, en la dieta, de la vitamina a desde su nacimiento hasta los 50 d\u00edas de vida. Transcurrido ese tiempo, se realiz\u00f3 un estudio de la ultraestructura de la  membrana basal renal mediante microscop\u00eda electr\u00f3nica, seguido de una cuantificaci\u00f3n del col\u00e1geno iv total, principal componente proteico de la membrana basal, as\u00ed como de las seis cadenas a que lo constituyen, mediante inmunocitoqu\u00edmica y western blotting. Adem\u00e1s se cuantificaron las metaloproteasas mmp2 y mmp9, analizando tambi\u00e9n su actividad proteol\u00edtica, as\u00ed como sus inhibidores tisulares timp-1 y timp-2.  seguidamente se valoraron vario<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones inducidas por dieta deficiente en vitamina a sobre membrana basal de ri\u00f1on de rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones inducidas por dieta deficiente en vitamina a sobre membrana basal de ri\u00f1on de rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Del Pilar Marin Muela <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/12\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joaquin Timoneda Timoneda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Cabo soler <\/li>\n<li>erwin Kenecht roberto (vocal)<\/li>\n<li>Mar\u00eda  del carmen Risue\u00f1o almeida (vocal)<\/li>\n<li>federico Pallard\u00f3 calatayud (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Del Pilar Marin Muela La deficiencia en vitamina a es un grave y com\u00fan trastorno nutricional, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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