{"id":77640,"date":"2005-10-12T00:00:00","date_gmt":"2005-10-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-de-regulacion-de-la-senalizacion-via-amp-ciclico-del-receptor-de-melanocortinas-1\/"},"modified":"2005-10-12T00:00:00","modified_gmt":"2005-10-12T00:00:00","slug":"mecanismos-de-regulacion-de-la-senalizacion-via-amp-ciclico-del-receptor-de-melanocortinas-1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/mecanismos-de-regulacion-de-la-senalizacion-via-amp-ciclico-del-receptor-de-melanocortinas-1\/","title":{"rendered":"Mecanismos de regulaci\u00f3n de la se\u00f1alizaci\u00f3n via amp ciclico del receptor de melanocortinas 1"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jes\u00fas Manuel Sanchez Mas <\/strong><\/h2>\n<p>Laos melanocitos son c\u00e9lulas altamente especializadas cuya principal funci\u00f3n conocida en la piel es la producci\u00f3n y distribuci\u00f3n de las melaninas por la piel, y por lo tanto la pigmentaci\u00f3n humana. Las melanocortinas, y m\u00e1s espec\u00edficamente la hormona estimulante del melanocito (msh), juegan un papel central en la regulaci\u00f3n de dichos procesos, tanto en condiciones basales como tras la exposici\u00f3n a radiaci\u00f3n uv. El efecto estimulador de msh en el melanocitos se produce por uni\u00f3n a un receptor espec\u00edfico perteneciente a la superfamilia de los receptores acoplados a prote\u00ednas g (gpcrs), el receptor de melanocortinas 1 (mc1r).  dicha uni\u00f3n activa la cascada del ampc que a su vez provoca la activaci\u00f3n de la bios\u00edntesis de melaninas. Adem\u00e1s, una alteraci\u00f3n en alguno de estos pasos puede provocar trastornos que originen patolog\u00edas de gravedad diferente, que van desde des\u00f3rdenes pigmentarlos hasta diversos tipos de c\u00e1ncer de piel, como es el caso del melanoma. Por tanto, uno de los aspectos esenciales en la regulaci\u00f3n de la melanog\u00e9nesis y en la biolog\u00eda del melanocito es la funcionalidad del mc1r. De esta manera los objetivos de nuestra investigaci\u00f3n se centraron en el estudio de los mecanismos de regulaci\u00f3n que modulan la se\u00f1alizaci\u00f3n del receptor de melanocortinas 1 en melanocitos y en c\u00e9lulas de melanoma humano (mc1r) y murino (mc1r). Dicha modulaci\u00f3n puede ejercerse a varios niveles que regulen la expresi\u00f3n del receptor en la membrana plasm\u00e1ticas del melanocitos, as\u00ed como su capacidad de se\u00f1alizaci\u00f3n. Las conclusiones m\u00e1s importantes de este estudio han sido.  1,- en c\u00e9lulas de melanoma y en melanocitos normales la cantidad de mol\u00e9culas de mc1r expresadas en membrana determina el nivel de la respuesta al agonista, lo que identifica al receptor como el factor limitante en la ruta de transducci\u00f3n de se\u00f1ales en estas c\u00e9lulas.  2,- la nueva variante natural l93r e mc1r encontrada en una l\u00ednea de c\u00e9l<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos de regulaci\u00f3n de la se\u00f1alizaci\u00f3n via amp ciclico del receptor de melanocortinas 1<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos de regulaci\u00f3n de la se\u00f1alizaci\u00f3n via amp ciclico del receptor de melanocortinas 1 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jes\u00fas Manuel Sanchez Mas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/12\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>borr\u00f3n Mart\u00ednez Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Lozano teruel Jos\u00e9 Antonio <\/li>\n<li>Jos\u00e9 Antonio Ferragut rodriguez (vocal)<\/li>\n<li>asuncion Cremades campos (vocal)<\/li>\n<li>joaquin Garc\u00eda-esta\u00f1 l\u00f3pez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jes\u00fas Manuel Sanchez Mas Laos melanocitos son c\u00e9lulas altamente especializadas cuya principal funci\u00f3n conocida en la piel [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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