{"id":77664,"date":"2005-12-12T00:00:00","date_gmt":"2005-12-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-de-los-efectos-de-clopidogrel-y-aspirina-sobre-la-pared-arterial-tras-lesion-intimal-en-animales-sanos-o-ateromatosos\/"},"modified":"2005-12-12T00:00:00","modified_gmt":"2005-12-12T00:00:00","slug":"estudios-de-los-efectos-de-clopidogrel-y-aspirina-sobre-la-pared-arterial-tras-lesion-intimal-en-animales-sanos-o-ateromatosos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudios-de-los-efectos-de-clopidogrel-y-aspirina-sobre-la-pared-arterial-tras-lesion-intimal-en-animales-sanos-o-ateromatosos\/","title":{"rendered":"Estudios de los efectos de clopidogrel y aspirina sobre la pared arterial tras lesion intimal en animales sanos o ateromatosos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Grajal Martinez <\/strong><\/h2>\n<p>Introducci\u00f3n  el prop\u00f3sito de este trabajo de investigaci\u00f3n ha sido valorar de manera experimental los efectos de un factor de riesgo aterog\u00e9nico sobre el desarrollo de la lesi\u00f3n ateromatosa de la pared arterial con lesi\u00f3n intimal y bajo la administraci\u00f3n de aspirina o clopidogrel.  material y m\u00e9todos  para llevar a cabo nuestro trabajo hemos utilizado 72 conejos de la raza noezeland\u00e9s gigante-espa\u00f1ol. Los conejos eran de ambos sexos, con un peso aproximado de 750 g., Y se dividieron en dos subgrupos de 36 animales cada uno, administrando a uno una dieta aterog\u00e9nica y al otro una dieta standard durante 30 d\u00edas; a su vez a cada subgrupo se divide en dos subgrupos de 18 animales cada uno provocando a una lesi\u00f3n intimal mediante cat\u00e9ter-bal\u00f3n de fogarty de 3 fr y al otro no; y por \u00faltimo a cada subgrupo se le divide en tres subgrupos de 6 animales cada uno, administrando aspirina a dosis de 1mg\/kg; clopidogrel a dosis de 2 mg\/kg o placebo, seg\u00fan el grupo asignado, durante 30 d\u00edas. Posteriormente se realiza una valoraci\u00f3n cl\u00ednica, c\u00e1lculo de la tasa de mortalidad, un estudio microsc\u00f3pico, un estudio macrosc\u00f3pico y un an\u00e1lisis morfom\u00e9trico y estad\u00edstico de los resultados.  resultados  en el grupo aterogenenicos + lesi\u00f3n intimal la administraci\u00f3n de clopidogrel y aspirina da lugar a una menor intensidad de las lesiones, as\u00ed como en el grupo con aterog\u00e9nesis como \u00fanico factor y en el grupo con lesi\u00f3n intimal como \u00fanico factor, tanto en la valoraci\u00f3n cl\u00ednica como desde el punto de vista morfol\u00f3gico y morfom\u00e9trico. Las lesiones m\u00e1s desarrolladas se han desarrollado en el grupo aterog\u00e9nico+lesi\u00f3n intimal.  conclusiones  el tratamiento tanto de aspirina como clopidogrel tiene una acci\u00f3n beneficiosa en la prevenci\u00f3n tanto del desarrollo de las lesiones inducidas en los vasos por dietas aterog\u00e9nicas como de los fen\u00f3menos tromb\u00f3ticos producidos por la lesi\u00f3n intimal. No se ha podido demostrar un may<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudios de los efectos de clopidogrel y aspirina sobre la pared arterial tras lesion intimal en animales sanos o ateromatosos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudios de los efectos de clopidogrel y aspirina sobre la pared arterial tras lesion intimal en animales sanos o ateromatosos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Grajal Martinez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/12\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Vaquero Puerta<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fernando Fern\u00e1ndez de la gandara <\/li>\n<li>Mar\u00eda  angeles Alller reyero (vocal)<\/li>\n<li>Mar\u00eda  victoria Diago santamaria (vocal)<\/li>\n<li>rosa Moreno carriles (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Grajal Martinez Introducci\u00f3n el prop\u00f3sito de este trabajo de investigaci\u00f3n ha sido valorar de manera experimental [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,12451],"tags":[9258,167185,12638,12620,12622,133992],"class_list":["post-77664","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-valladolid","tag-carlos-vaquero-puerta","tag-carmen-grajal-Martinez","tag-fernando-fernandez-de-la-gandara","tag-maria-angeles-alller-reyero","tag-maria-victoria-diago-santamaria","tag-rosa-moreno-carriles"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/77664","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=77664"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/77664\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=77664"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=77664"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=77664"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}