{"id":77673,"date":"2005-12-12T00:00:00","date_gmt":"2005-12-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-del-factor-de-necrosis-tumoral-alfa-tnf-alfa-y-de-la-inerleucina-1-beta-il-ibeta-en-la-disfuncion-mitocondrial-del-condrocito-articular-humano-estudio-en-el-proceso-apoptotico\/"},"modified":"2005-12-12T00:00:00","modified_gmt":"2005-12-12T00:00:00","slug":"implicacion-del-factor-de-necrosis-tumoral-alfa-tnf-alfa-y-de-la-inerleucina-1-beta-il-ibeta-en-la-disfuncion-mitocondrial-del-condrocito-articular-humano-estudio-en-el-proceso-apoptotico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/implicacion-del-factor-de-necrosis-tumoral-alfa-tnf-alfa-y-de-la-inerleucina-1-beta-il-ibeta-en-la-disfuncion-mitocondrial-del-condrocito-articular-humano-estudio-en-el-proceso-apoptotico\/","title":{"rendered":"Implicaci\u00f3n del factor de necrosis tumoral alfa (tnf alfa) y de la inerleucina 1 beta (il-ibeta) en la disfunci\u00f3n mitocondrial del condrocito articular humano: estudio en el proceso apopt\u00f3tico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Beatriz Caram\u00e9s P\u00e9rez <\/strong><\/h2>\n<p>La artrosis (oa) es una patolog\u00eda asociada al envejecimiento que se caracteriza por la destrucci\u00f3n del cart\u00edlago articular. Los estudios histol\u00f3gicos del cart\u00edlago oa muestran un incremento en el n\u00famero de condrocitos apopt\u00f3ticos y una p\u00e9rdida de matriz extracelular (mec). Sin embargo, la etiolog\u00eda exacta de la oa esta lejos de ser totalmente entendida, debido a que, son muchos los factores que intervienen en la destrucci\u00f3n del cart\u00edlago, provocando a largo plazo la aparici\u00f3n de la oa. Dos de estos factores son el tnf alfa y la il-1 beta, dos citocinas catab\u00f3licas implicadas en procesos inflamatorios. no obstante, el mecanismo exacto por el que estas citocinas modulan la degradaci\u00f3n del cart\u00edlago permanece sin responder.  clasicamente las alteraciones de la mitocondria se han estudiado asociadas a patolog\u00edas cong\u00e9nitas como las miopat\u00edas mitocondriales. Sin embargo, en los \u00faltimos a\u00f1os se han encontrado evidencias que demuestran alteraciones mitocondriales en enfermedades cr\u00f3nicas y asociadas al envejecimiento como la enfermedad de alzheimer, el parkinson y la diabetes. En este sentido, algunas investigaciones recientes relacionan las alteraciones de la mitocondria con la oa. Las mitocondrias de los condrocitos aumentan en tama\u00f1o y n\u00famero en la zona superficial y media del cart\u00edlago cuando la oa empieza a establecerse. asimismo, nuestro grupo ha demostrado que la actividad de los complejos ii y iii de la cadena respiratoria mitocondrial (crm) y el potencial de membrana mitocondrial (avm) est\u00e1 disminuido en el condrocito oa en relacio\u00f3n con el condrocito normal.  los resultados que se exponen en esta tesis doctoral demuestran: (1) que el tnf-alfa y la il-1 beta alteran la funci\u00f3n mitocondrial del condrocito, modificando el transporte de electrones mitocondrial a nivel del complejo i de la crm y disminuyendo el avm y la producci\u00f3n de atp. Adem\u00e1s, demostramos que la inhibici\u00f3n del complejo i disminuye el conteni<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaci\u00f3n del factor de necrosis tumoral alfa (tnf alfa) y de la inerleucina 1 beta (il-ibeta) en la disfunci\u00f3n mitocondrial del condrocito articular humano: estudio en el proceso apopt\u00f3tico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaci\u00f3n del factor de necrosis tumoral alfa (tnf alfa) y de la inerleucina 1 beta (il-ibeta) en la disfunci\u00f3n mitocondrial del condrocito articular humano: estudio en el proceso apopt\u00f3tico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Beatriz Caram\u00e9s P\u00e9rez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 A coru\u00f1a<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/12\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Javier Blanco Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco javier Cudeiro mazaira <\/li>\n<li>Miguel angel Martin casanueva (vocal)<\/li>\n<li>esperanza Cerdan villanueva (vocal)<\/li>\n<li>Jos\u00e9 Luis Pablos alvarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Beatriz Caram\u00e9s P\u00e9rez La artrosis (oa) es una patolog\u00eda asociada al envejecimiento que se caracteriza por la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[18576,849,35,9,9399,69,139],"tags":[167199,19578,53967,35181,62668,47630],"class_list":["post-77673","post","type-post","status-publish","format-standard","hentry","category-a-coruna","category-biologia-celular","category-ciencias-de-la-vida","category-ciencias-medicas","category-cultivo-celular","category-enfermedades-pulmonares","category-medicina-interna","tag-beatriz-carames-perez","tag-esperanza-cerdan-villanueva","tag-francisco-javier-blanco-garcia","tag-francisco-javier-cudeiro-mazaira","tag-jose-luis-pablos-alvarez","tag-miguel-angel-martin-casanueva"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/77673","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=77673"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/77673\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=77673"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=77673"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=77673"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}