{"id":77700,"date":"2018-03-09T23:23:17","date_gmt":"2018-03-09T23:23:17","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/receptores-serotonergicos-5-ht1a-en-sistema-nervioso-central-modulacion-alosterica-y-regulacion-por-farmacos-antidepresivos\/"},"modified":"2018-03-09T23:23:17","modified_gmt":"2018-03-09T23:23:17","slug":"receptores-serotonergicos-5-ht1a-en-sistema-nervioso-central-modulacion-alosterica-y-regulacion-por-farmacos-antidepresivos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacos-psicotropicos\/receptores-serotonergicos-5-ht1a-en-sistema-nervioso-central-modulacion-alosterica-y-regulacion-por-farmacos-antidepresivos\/","title":{"rendered":"Receptores seroton\u00e9rgicos 5-ht1a en sistema nervioso central: modulaci\u00f3n alost\u00e9rica y regulaci\u00f3n por f\u00e1rmacos antidepresivos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sergio Barrondo Lakarra <\/strong><\/h2>\n<p>El trabajo realizado en esta tesis doctoral ha pretendido cubrir dos objetivos fundamentales: por un lado, estudiar exhaustivamente la farmacolog\u00eda del receptor ser ton\u00e9rigco 5-ht1a, valorando la modulaci\u00f3n farmacol\u00f3gica que ejercen sobre dicho receptor tanto compuestos end\u00f3genos (cati\u00f3n zinc) como distintos f\u00e1rmacos antidepresivos (imaos e isrss): y por otro lado, estudiar la regulaci\u00f3n que ejerce el tratamiento cr\u00f3nico con f\u00e1rmacos antidepresivos sobre los niveles de expresi\u00f3n de los receptores seroton\u00e9rgicos 5-ht1a y de sus prote\u00ednas transductoras, las prote\u00ednas g del subtipo gi\/o.     los resultados obtenidos tras cubrir el primer objetivo de este trabajo demuestran que el cati\u00f3n zinc es capaz de modular alost\u00e9ricamente la fijaci\u00f3n de ligandos al receptor seroton\u00e9rgico 5-ht1a a concentraciones de orden micromolar, dentro del rango de concentraciones de zinc que pueden alcanzarse fisiol\u00f3gicamente en determinadas sinapsis. Estos resultados son de gran inter\u00e9s ya que se\u00f1alan la capacidad de zinc para ctaur como un modulador alost\u00e9rico end\u00f3geno del receptor seroton\u00e9rigco 5-ht1a, e indican la posibilidad de que dicho cati\u00f3n imprima un cierto matiz regional en sistema nervioso central a la transmisi\u00f3n seroton\u00e9rgica mediada por el receptor 5-ht1a.  de igual forma, distintos f\u00e1rmacos antidepresivos probados en este trabajo muestran capacidad para interacciones de forma alost\u00e9rica con el receptor seroton\u00e9rgico 45-ht1a, tambi\u00e9n a concentraciones de orden micromolar, revel\u00e1ndose por tanto un mecanismo bioqu\u00edmico adicional que puede estar contribuyendo al efecto neto global observado tras el tratamiento cr\u00f3nico con dichos f\u00e1rmacos.     en el segundo apartado de esta tesis doctoral se valora el efecto que produce el tratamiento cr\u00f3nico con fluoxetina sobre los niveles de expresi\u00f3n de receptor seroton\u00e9rigoc 5-ht1a y se sus prote\u00ednas transuctoras en dos regiones distintas, corteza e hipocampo. Interesantemente, previo a realizar esta<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Receptores seroton\u00e9rgicos 5-ht1a en sistema nervioso central: modulaci\u00f3n alost\u00e9rica y regulaci\u00f3n por f\u00e1rmacos antidepresivos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Receptores seroton\u00e9rgicos 5-ht1a en sistema nervioso central: modulaci\u00f3n alost\u00e9rica y regulaci\u00f3n por f\u00e1rmacos antidepresivos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sergio Barrondo Lakarra <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/12\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joan Salles Alvira<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Castro fern\u00e1ndez m. Elena (secretario) <\/li>\n<li>Jes\u00fas Andr\u00e9s Garcia sevilla (vocal)<\/li>\n<li>Jos\u00e9 Javier Meana Martinez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sergio Barrondo Lakarra El trabajo realizado en esta tesis doctoral ha pretendido cubrir dos objetivos fundamentales: por [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[183,12909],"tags":[167241,13467,14031,10654,167240],"class_list":["post-77700","post","type-post","status-publish","format-standard","hentry","category-farmacos-psicotropicos","category-pais-vasco-euskal-herriko-unibertsitatea","tag-castro-fernandez-m-elena-secretario","tag-jesus-andres-garcia-sevilla","tag-joan-salles-alvira","tag-jose-javier-meana-Martinez","tag-sergio-barrondo-lakarra"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/77700","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=77700"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/77700\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=77700"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=77700"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=77700"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}