{"id":77747,"date":"2018-03-09T23:23:17","date_gmt":"2018-03-09T23:23:17","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-funcional-de-la-accion-neuroprotectora-y-neurotoxica-de-los-tratamientos-quirurgicos-y-farmacologicos-en-un-modelo-de-rata-parkinsonizada\/"},"modified":"2018-03-09T23:23:17","modified_gmt":"2018-03-09T23:23:17","slug":"estudio-funcional-de-la-accion-neuroprotectora-y-neurotoxica-de-los-tratamientos-quirurgicos-y-farmacologicos-en-un-modelo-de-rata-parkinsonizada","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/accion-de-los-farmacos\/estudio-funcional-de-la-accion-neuroprotectora-y-neurotoxica-de-los-tratamientos-quirurgicos-y-farmacologicos-en-un-modelo-de-rata-parkinsonizada\/","title":{"rendered":"Estudio funcional de la acci\u00f3n neuroprotectora y neurot\u00f3xica de los tratamientos quir\u00fargicos y farmacol\u00f3gicos en un modelo de rata parkinsonizada"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gaizka Bilbao Barandika <\/strong><\/h2>\n<p>La enfermedad del parkinson es la segunda enfermedad neurodegenerativa m\u00e1s frecuente. Esto implica que numerosos recursos econ\u00f3micos sean destinados al tratamiento y cuidado de estos enfermos. el tratamiento m\u00e9dico est\u00e1 dominado por la levodopa: sin embargo, los pacientes que con el tiempo sufren complicaciones motoras secundarias a la evoluci\u00f3n de la propia enfermedad son ributarios de tratamiento quir\u00fargico (lesi\u00f3n o estimulaci\u00f3n del n\u00facleo subtal\u00e1mico). Al desconocerse la etiolog\u00eda de la enfermedad es imposible un tratamiento preventivo. Sin embargo, se est\u00e1 haciendo \u00e9nfasis en la posible neuroprotecci\u00f3n atribuida a determinados f\u00e1rmacos o tratamientos quir\u00fargicos. invest\u00edamos las caracter\u00edsticas electrofisiol\u00f3gicas de las neuronas dopamin\u00e9rgicas de la sustancia negra compacta en un modelo de rata parcialmente parkinsonizada. Observamos que estas c\u00e9lulas descargaban de una forma m\u00e1s irregular (aumento del coeficiente de variaci\u00f3n) que las controles. Sin embargo, el an\u00e1lisis de la frecuencia de descarga, el n\u00famero de descargas en salva y el n\u00famero de descargas por salva era similar en ambos grupos. Daba consistencia a nuestro modelo el hecho de que la lesi\u00f3n nigroestriatal, medida a trav\u00e9s de un contaje celular directo en la sustancia negra (y compar\u00e1ndolo con el hemisferio contralateral intacto) presentaba una correlaci\u00f3n directa con la lesi\u00f3n estriatal (medida a trav\u00e9s del estudio de escala de grises-densidades \u00f3pticas-). Adem\u00e1s, el n\u00famero de neuronas electrofisiol\u00f3gicamente actas (n\u00famero de neuronas registradas por trayecto) era significativamente menor en las ratas lesionadas. por otra parte, se estudi\u00f3 el efecto que un tratamiento con levodopa en infusi\u00f3n continua ten\u00eda sobre los anteriores par\u00e1metros electrofisiol\u00f3gicos e inmunohsitoqu\u00edmicos. Observamos que la levodopa era capaz de revertir la irregularidad de las neuronas dopamin\u00e9rgicas lesionadas a valores normales, lo cual entendimos como un efecto de recupe<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio funcional de la acci\u00f3n neuroprotectora y neurot\u00f3xica de los tratamientos quir\u00fargicos y farmacol\u00f3gicos en un modelo de rata parkinsonizada<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio funcional de la acci\u00f3n neuroprotectora y neurot\u00f3xica de los tratamientos quir\u00fargicos y farmacol\u00f3gicos en un modelo de rata parkinsonizada <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gaizka Bilbao Barandika <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/12\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Garibi Undabarrena<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Mendez martin <\/li>\n<li>Jaime Broseta rodrigo (vocal)<\/li>\n<li>Miguel Gelabert gonz\u00e1lez (vocal)<\/li>\n<li>justo Garc\u00eda  de y\u00e9benes (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gaizka Bilbao Barandika La enfermedad del parkinson es la segunda enfermedad neurodegenerativa m\u00e1s frecuente. Esto implica que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[44,392,1880,12909],"tags":[167317,12430,10122,158874,19019,21675],"class_list":["post-77747","post","type-post","status-publish","format-standard","hentry","category-accion-de-los-farmacos","category-neurocirugia","category-neurologia","category-pais-vasco-euskal-herriko-unibertsitatea","tag-gaizka-bilbao-barandika","tag-jaime-broseta-rodrigo","tag-jaime-mendez-martin","tag-jesus-garibi-undabarrena","tag-justo-garcia-de-yebenes","tag-miguel-gelabert-gonzalez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/77747","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=77747"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/77747\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=77747"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=77747"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=77747"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}