{"id":77771,"date":"2018-03-09T23:23:21","date_gmt":"2018-03-09T23:23:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estres-oxidativo-y-fibrogenesis-en-la-diabetes-mellitus-tipo-1-influencia-del-control-glucemico-y-del-consumo-de-tabaco\/"},"modified":"2018-03-09T23:23:21","modified_gmt":"2018-03-09T23:23:21","slug":"estres-oxidativo-y-fibrogenesis-en-la-diabetes-mellitus-tipo-1-influencia-del-control-glucemico-y-del-consumo-de-tabaco","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/endocrinologia\/estres-oxidativo-y-fibrogenesis-en-la-diabetes-mellitus-tipo-1-influencia-del-control-glucemico-y-del-consumo-de-tabaco\/","title":{"rendered":"Estr\u00e9s oxidativo y fibrog\u00e9nesis en la diabetes mellitus tipo 1: influencia del control gluc\u00e9mico y del consumo de tabaco"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Lilliam Flores Meneses <\/strong><\/h2>\n<p>Las complicaciones de la dm son el resultado de la interacci\u00f3n de m\u00faltiples factores patog\u00e9nicos y la causa de un importante morbilidad y mortalidad en un segmento amplio de nuestra poblaci\u00f3n. La base de esta tesis ha sido estudiar el efecto de dos noxas, la hiperglucemia, y el consumo de tabaco, sobre las concentraci\u00f3n de f2-isops, como expresi\u00f3n de estr\u00e9s oxidativo y de el tgfb1, como marcador de fibrog\u00e9nesis, que son dos v\u00edas metab\u00f3licas, estrechamente asociadas al desarrollo de las complicaciones cr\u00f3nicas de la dm. Durante el dise\u00f1o de esta tesis, la informaci\u00f3n que exist\u00eda respecto al a modulaci\u00f3n de ambas v\u00edas patog\u00e9nicas era escasas y se centraba en fases avanzadas en la enfermedad. Valorar el estr\u00e9s ocisativo y la fibrog\u00e9nesis al inicio de la dm nos permit\u00eda analizar de forma espec\u00edfica el papel de la hiperglucemia, pero tambi\u00e9n nos posibilitaba describir su actividad en una fase de la enfermedad hasta ahora no estudiada. El consumo de tabaco es otro factor de riesgo definido para el desarrollo de las complicaciones cr\u00f3nicas de la dm de creciente inter\u00e9s cl\u00ednico y del cual no existe informaci\u00f3n en pacientes con dma respecto a su posible efecto sobre los factores analizados en este trabajo.     en resumen, en este trabajo hemos podido demostrar que tanto el estr\u00e9s oxidativo como la fibrof\u00e9nesis est\u00e1n aumentadas ya en fases precoces de la enfermedad, as\u00ed como la existencia de una relaci\u00f3n directa entre la hiperglucemia y el estr\u00e9s oxidativo. El modelo cl\u00ednico utilizado para valorar el efecto de la hiperglucemia sobre la fibrog\u00e9nesis no nos permiti\u00f3 extraer conclusiones definitivas, ya que la actividad del tgfb1, estaba probablemente influida por el proceso autoinmune que destru\u00eda las c\u00e9lulas b del p\u00e1ncreas en estos sujetos. Por otra parte, se confirm\u00f3 que el consumo de tabaco estimula directamente la actividad de ambas v\u00edas patog\u00e9nicas implicadas en la patog\u00e9nesis de las complicaciones cr\u00f3nicas, explicando as\u00ed, las<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estr\u00e9s oxidativo y fibrog\u00e9nesis en la diabetes mellitus tipo 1: influencia del control gluc\u00e9mico y del consumo de tabaco<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estr\u00e9s oxidativo y fibrog\u00e9nesis en la diabetes mellitus tipo 1: influencia del control gluc\u00e9mico y del consumo de tabaco <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Lilliam Flores Meneses <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/12\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Enric Esmatjes Mompo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Coca <\/li>\n<li>anna Sanmart\u00ed (vocal)<\/li>\n<li>rafa Sim\u00f3 (vocal)<\/li>\n<li>Marta Vives (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lilliam Flores Meneses Las complicaciones de la dm son el resultado de la interacci\u00f3n de m\u00faltiples factores [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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