{"id":77786,"date":"2018-03-09T23:23:21","date_gmt":"2018-03-09T23:23:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/spect-cerebral-polimorfismo-del-gen-apoe-y-valoracion-neuropsicologica-en-la-prediccion-de-la-evolucion-de-los-pacientes-con-deterioro-cognitivo-ligero-a-enfermedad-de-alzheimer\/"},"modified":"2018-03-09T23:23:21","modified_gmt":"2018-03-09T23:23:21","slug":"spect-cerebral-polimorfismo-del-gen-apoe-y-valoracion-neuropsicologica-en-la-prediccion-de-la-evolucion-de-los-pacientes-con-deterioro-cognitivo-ligero-a-enfermedad-de-alzheimer","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/spect-cerebral-polimorfismo-del-gen-apoe-y-valoracion-neuropsicologica-en-la-prediccion-de-la-evolucion-de-los-pacientes-con-deterioro-cognitivo-ligero-a-enfermedad-de-alzheimer\/","title":{"rendered":"Spect cerebral, polimorfismo del gen apoe y valoraci\u00f3n neuropsicol\u00f3gica en la predicci\u00f3n de la evoluci\u00f3n de los pacientes con deterioro cognitivo ligero a enfermedad de alzheimer"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Encinas Mejias <\/strong><\/h2>\n<p>Objetivos     definir marcadores predictivos que puedan identificar a aquellos pacientes con dcl que van a evolucionar hacia una ea probable.  material y m\u00e9todos     se realiz\u00f3 un estudio de cohortes prospectivo con 42 pacientes que cumpl\u00edan criterios de dcl. El estudio neuropsicol\u00f3gico incluy\u00f3 los siguientes test: mec, camcog, rivermead y benton y la escala de wais. Se calcul\u00f3 el flujo sangu\u00edneo cerebral regional mediante 99mtc-ecd-spect y se determinaron 17 \u00e1reas de inter\u00e9s (adi). Se determin\u00f3 el polimorfismo del apoe. Se realiz\u00f3 un seguimiento cl\u00ednico mediano de los 42 pacientes durante al menos dos a\u00f1os (iqr p25-p75: 21-36 meses). 21 pacientes pasaron a cumplir criterios de ea probable (grupo i) y 21 pacientes mantuvieron el diagn\u00f3stico de dcl (grupo ii). Se construyeron curvas cor y se calcularon los \u00edndices de sensibilidad, especificidad, valor predictivo positivo y negativo y cocientes de probabilidad positivo y negativo a posteriori.  resultados     no se encontraron diferencias significativas en los datos  sociodemogr\u00e1ficos entre ambos grupos. El grupo i muestra diferencias significativas en las puntuaciones de los test mec, rivermead, camcog global y sus \u00edtems: orientaci\u00f3n, lenguaje, memoria, c\u00e1lculo y percepci\u00f3n de la escalas de benton y de blessed respecto al grupo ii. Las variables que diferenciaban mejor los dos grupos son el camcog global y sus \u00edtems: percepci\u00f3n, orientaci\u00f3n y memoria. El grupo i tiene un \u00edndice relativo de flujo (irf) entre un 7-10% menor que el grupo ii en las \u00e1reas pfd, pfi, frd, fri, pad, pai, fptd, fpti, ted, tei y telpi. Las \u00e1reas que muestran sensibilidades y especificidades mayores del 75% y \u00e1reas bajo la curva cir pr\u00f3ximas al 80% son: pfi, pai, fri, frd y pfd. Las puntuaciones del camcog global, de su \u00edtem orientaci\u00f3n y el irf del \u00e1rea fri son los factores predictivos independientes del riesgo de progresi\u00f3n del dcl a ea. No se encontraron diferencias en la frecuencia al\u00e9lica del ap<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Spect cerebral, polimorfismo del gen apoe y valoraci\u00f3n neuropsicol\u00f3gica en la predicci\u00f3n de la evoluci\u00f3n de los pacientes con deterioro cognitivo ligero a enfermedad de alzheimer<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Spect cerebral, polimorfismo del gen apoe y valoraci\u00f3n neuropsicol\u00f3gica en la predicci\u00f3n de la evoluci\u00f3n de los pacientes con deterioro cognitivo ligero a enfermedad de alzheimer <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Encinas Mejias <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/12\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Cabranes D\u00edaz Jos\u00e9 Antonio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fernando Armaiz bueno <\/li>\n<li>Francisco Jos\u00e9 Vaz leal (vocal)<\/li>\n<li>demetrio Crespo facurro (vocal)<\/li>\n<li> Arias navarro Jos\u00e9 Antonio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Encinas Mejias Objetivos definir marcadores predictivos que puedan identificar a aquellos pacientes con dcl que van 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