{"id":77830,"date":"2018-03-09T23:23:25","date_gmt":"2018-03-09T23:23:25","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estado-oxidativo-metabolico-y-afectacion-retiniana-en-diabetes-mellitus-e-hipertension-arterial-seguimiento-a-cinco-anos\/"},"modified":"2018-03-09T23:23:25","modified_gmt":"2018-03-09T23:23:25","slug":"estado-oxidativo-metabolico-y-afectacion-retiniana-en-diabetes-mellitus-e-hipertension-arterial-seguimiento-a-cinco-anos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estado-oxidativo-metabolico-y-afectacion-retiniana-en-diabetes-mellitus-e-hipertension-arterial-seguimiento-a-cinco-anos\/","title":{"rendered":"Estado oxidativo-metab\u00f3lico y afectaci\u00f3n retiniana en diabetes mellitus e hipertensi\u00f3n arterial. seguimiento a cinco a\u00f1os."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Javier Garc\u00eda Medina <\/strong><\/h2>\n<p>El estr\u00e9s oxidativo (desequilibrio entre la producci\u00f3n y neutralizaci\u00f3n de radicales libres, a favor de la primera) se ha implicado en la etiopatogenia de numerosas patolog\u00edas seg\u00fan la literatura. En el presente estudio se analiza el papel del estr\u00e9s oxidativo as\u00ed como la influencia de la suplementaci\u00f3n con un complejo vitam\u00ednico-mineral con propiedades antioxidantes (dosis nutricionales) en grupos de individuos diab\u00e9ticos, hipertensos y sanos, haciendo especial hincapi\u00e9 en la valoraci\u00f3n de las retinopat\u00edas diab\u00e9tica e hipertensiva leves-moderadas en un seguimiento durante 5 a\u00f1os.  para ello se seleccionaron un total de 604 individuos en 1999 (distribuidos en grupo de diabetes, grupo de hipertensi\u00f3n y grupo de controles sanos) a los que se les realiz\u00f3 una anamnesis detallada (contemplando posibles factores de riesgo de retinopat\u00eda), medici\u00f3n de la tensi\u00f3n arterial diast\u00f3lica (tad), una exploraci\u00f3n oftalmol\u00f3gica completa y una determinaci\u00f3n en sangre de par\u00e1metros cl\u00e1sicos (glucemia, hemoglobina glicosilada, colesterol total, hdl, ldl, urea y creatinina) y de par\u00e1metros emergentes indicadores del balance oxidativo-antioxidante (malonildialdeh\u00eddo (mda), actividad antioxidante total y actividad super\u00f3xido dismutasa). Parte de la muestra fue asignada aleatoriamente a suplementaci\u00f3n antioxidante. Se realizaron revisiones anuales para evidenciar cambios cl\u00ednicos, reforzar la ingesta del suplemento y anotar posibles cambios de filiaci\u00f3n.  al final del seguimiento (2004) se les realiz\u00f3 una anamnesis, exploraci\u00f3n cl\u00ednica y anal\u00edtica id\u00e9ntica a la inicial a los 490 individuos que siguieron en el estudio.  se evidenci\u00f3 que el balance de las actividades oxidativas estaba alterado en los grupos de la diabetes mellitus y de la hipertensi\u00f3n arterial, a favor del estr\u00e9s oxidativo, respecto al grupo de controles sanos. Se realizaron estudios de correlaci\u00f3n entre los distintos par\u00e1metros, obteniendo asociaci\u00f3n s<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estado oxidativo-metab\u00f3lico y afectaci\u00f3n retiniana en diabetes mellitus e hipertensi\u00f3n arterial. seguimiento a cinco a\u00f1os.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estado oxidativo-metab\u00f3lico y afectaci\u00f3n retiniana en diabetes mellitus e hipertensi\u00f3n arterial. seguimiento a cinco a\u00f1os. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Javier Garc\u00eda Medina <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/12\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Pinazo Dur\u00e1n  M\u00aa Dolores<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Santiago Grisol\u00eda Garc\u00eda <\/li>\n<li>Elena Vecino cordero (vocal)<\/li>\n<li>Manuel Vidal sanz (vocal)<\/li>\n<li>Jos\u00e9 Garc\u00eda arumi (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Javier Garc\u00eda Medina El estr\u00e9s oxidativo (desequilibrio entre la producci\u00f3n y neutralizaci\u00f3n de radicales libres, a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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